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BÁCɁGNa>2p/+64">ob{sexpernte:resisc頥!variouspeciesan@ls@dhhod adȂp.hfo8givenmouthzined subcuelyA9toneal(v,muscHR. Asarcouleudgeappear,th*selrZIzbutIi s ssibl@iagnowiy8greccuracydi hiPڰ8,ostrtem@aeHَȀdmcasPhichissu2wqfatal. SiH]mmffugrJell @yg!+*employ;et,X, seasظBHb irugRftؘȌ؅p investig3 323ϡ͠5">ǡǀEXPERIMENTS_ON_RABBITSU6ȁGSNҁCh3JU7TfPetusirˡ- P4dicacedaagraph.om^rabbinːga 1daaoys0cluscarroؒse`dayreks v2d,}.ԙuaxsay442'U8qSUBANEOUS@JEC/Z9GUS@D4JUA">FromHstuxli`atuXxw@seem0thAb 150g il0s`obabڑc@jȱ Prelirbserv/QiȬ"su dXrpthqŁhardsuffIe symptomʂXmajo<4//.B8sp`title="[Pg 19]UC>P_19ggdDCSxhAG">[D147A167Hn7ϡϝ9.]NJǃHHi 5UI">R332.elgife@e.eigh1,0708ams.ĶigocJ">Mar25: 8.5c 2q&(158e)//) 2.15..; 4KeflexXX; 5.4L,bnȧ8m markedφK6:ҊSlooor;@US߂߂߂LJUM311oogN: , 97733gerilo)njectedubcutaneously; 4..,eflexesXcreased; 5.45conditionheame.

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February 27: 16c 2erentaffein (200gkilo)njectedubcutaneously at 3.40..;8creas@reflexesbservaboutneourftwas&, bHnothsymptoR 28:abbitoundead///+S">112.lackemale.eigh87WWWU">March 1(977357774t 33.3|,3becamestlesswere,remor 5,; 4.15had, handl thisaito duceeux1inut laIfhorturatioithcovery occurreO77$1691ao'''#2ooK03o19.ellowhite1,060_g]4">April 10188 2.@5ߊw6wwK07w95Ȋ??83?carrotspectob7߄τσ8">1430.2Ҋ11; 2.2convulsXsai ??9">Note:lcedof Ptumnotic_AρK0B208.ray8^-15,alusiveττσC15ό̌//+1 G^٫uq4ﭨmarkwhen l׆׆D16'0E':ooypoornourishGGGEF߁OK0G47xelgiharep\29ϧ0sP0aysfore ex8im8wgg_Hvem0x,rineta@dromheladdpacijlitmXX d8)ёgarrlbuІ_; 1.3Ă5 #)lkhy8dehg's soluIiBDsiabl(l do I蜁A$ȇNcollgavxoi`g`φ,symptom8diu: 31{ack (0.2kilo); 4.30..,eflexesuchxaggerated.

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November 10: 9..,oundead???;G">Rabbit 335.rayareHemale.eight, 1,170rams.ieMarch 31opril 7, carrotsi> I">܇(.30C14c 2centaffeinolution (240gkilo)njected󋇋 theack;p0,eflexesu increasedȈ{isxtremelyensitiveJ8|. Kutopsy:̃rasongesa`ptainqeal coccidiosnodules;tomadindxwith0rryod턀;aosahi milPathal8flammavoftȄhslsolȁegωLJLgK1Mf249.elgian{85yoaogoK1N 11:r, 5`romladda litmus,ГgarRalbumi`11.50 疙36adr; 3.45 Ė_yHæsXsia rkbutteXnh(hled; @uHllat 4EucBFehling'ssiabO 12:88_^eavyna@wubic imesbdednoc`gend؇B gKympXoxiLJLJLJPK1Q21.ellow13??6R">s16`947777;QǕǕæsHrun rp@floos@ceptrequiforhmovЪ)returog2cXsoft牯S[ąganor@doxeQwalkGGGCTF,r҉appet0$seems be///+U-255ܰllj_قV77K2050ga4ggltwoays be`exnٚ1"s5, 岂1,(252𱫛` wqʱ;6,___7__]2__o8x1'  Rf Qh??????<38sppgep@d00026"itle="[Pg 22]24aP _`ggc5`/a 1'6ρK27834ϛϛϛ270ϛɧ`rot@31iApril 7O//'8">?50mu-extPe>ggc9e_/߿ A//K2B33xh6729DŽDŽǃC 9.52ʍ238{bserv(ul ʍ託 weXic9?bre18" aid="6LK2D">November 10: 9..,aralysisfosteriorxtremities;iedt 1

AntheesultxbtaininexpmenYsesn1spection Table, page 25,howallourvabbiwhichurvivdos 236oH2g caffehiloereelgiana.ςJӊone lya .ԁorreeÁt. wos fat胉wo receRcarroduringvenays!dadministra$UэXt donot8embactor,9Xore,toxicityxMitay (obXy*o. 122,},df8aI2508 Ғ@same2ߐPn Ř;G">E`4*3@؂Ha`illuވP dependp0inceₘ%<,u causB symptomsaɊ[8prdtal!.t eviِe, dieQșpaqP-yX"ׄh0 8babil durac1bg@`Pva.Ғ335sncepъ-tem exaЎۆɒs2occidio70AQla, wс;condva@d(@smP0~'lWTHer?2H">SKD`Q>J">Tp2 regarW ousߛzxascerJڈstiureǁXgrayor ᤀbjȶ[xǭٗ8Іed¦ʧog ِhumUi35ŦXÛeekinٯӵ hd rangrom 267!30cyϗyotadultȶK"i52L">|253.rblack,lhWeigh1,60mD23Nmb912iM">12: 11.30..,x pdd,buXbsu;5 22c 2b(275/lo)subcuely45lumpeabl(hvulsrefheop0hotonos, generrePex ȷPetchIui/-alm nor,equtwi s;0t15NxO52feߑ۰aߑߑߑ߄ǃǃPߑߑ18'.ՓMEbBؔהӌ`,lxtgreHiAnotic9bhon; 4 ѧ8 d,%unusuXthsn lljbyons hה;c Abad2dђgK2QggK2Rf327hge82/War8:6?S">16"''!92''$ b;Qfoud,0sti0warm. T">Autopsy:Ȓqrhagic @apoiȵpimusc(;)abdo8*g exhQqarg@heesyurulmaal;v9spleHengod; fxs?U?'K2V?40

March 30: 3.20.., Pccf 2erentaffein (273gkilo)njectedubcutaneously hbackpWWWP1V1: 9;foundead'''#2">Rabbit 341hiteᇠbrownG@50GGG?G=7GGG//270////*; 4.4ƍˀdyingondition,adyvulss5 W8ǁK3926,犢6Њ,͉Z8o 16A1691H12o7744_777nheTP;tremorsrkedyPsenshvstariPrunhen putnloor;3was`tndlanyorerequirforimovalrom retur8oge?B7.30ņstillret‡Uoprwiseener@& good;x+ympto(C8pappe؊WT! diboȍԄWWWRDK3E235.elgi`harWV8pWcarroiNovemb829F">֗b1.05m2567; reflexescreasP,pteusbserveext xn GK3HЋfe86׃τ׃I1X.1Tsomewhat=tĂ8so;lhzxgaclumsyzslow;ofo2.35 Elp)Q,8steriȏ`x`endrigixanK Os0ra;path;ccaɟ8spasm. ܟ{ J">AutopsyY:epoi``i8 musc;쯘rpleengorgRXnzXans(ntnorH男KK3L9''w 41Mgustr1wgd8wgggg; 4OLmO; 5Asame,  N9,:ҨςςςO21,2Gpn 275lfu .P3~WǒoK3QWRLgXosaXfairwedii muc@raX1flammatoryg;Y t9 slquidInatuq@l eȴ  ZBancewwR'K3S'973oogT72f?=77~'''U'9 0.36WHy׶Ujumps2 touchid="6LK3V">August 21:eight, 1,245rams.njectedubcutaneously 275gfaffeiner kilo;eflexesncreased,osteriorxtremitistiffveroura(.

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Septemb27: 12pon,onvulsionsndeath. Autopsy:ost(fheungs; vleggL">M">Rabbit 423.hite,aleheight, 1,205rams.ieoati>''N6: 2%18cycentaffeindministeredyoo ootetanu7dibun{dO9fou3d/'?K7P/*L,iver,bkidneysed; sorganorgcQoK7R22440'S21(291gkilo)n O7TK3hvW֞sithXcoy,is wasxllowaiolattackb,hicha9bneinutequcceedparalysirdi.30׏K7Ulaly; aHloret(sh8ma;ότVspan逈pgepubid00033"itle="[Pg 28]80aPage_2ggb1`/a 12tudysexim0 ls0ideleariatoxicit9 Uwh.n(mexsao300loke8s,uIZsz424 ,Pppr@matep( saXs!́0ducponly.ԇE (No24824hf@jr25-33Go Panט(No39)rv@@63lHTh(Is cal, ppearsromJresulingT 419,P0421l!{beiv35N U26768o 342x,pectl09h fattxbbserAfurRteyaXmo(8a` :l8 Ta2XI>—A7}byuthpi>divtab_86"25"ata-summary="data"> SERIES.(r???6">Rabbito //>eightCaffeinerilo__\Symptoms'%DurationfifeggDie_X>eke7d7"/8hi15">GraiAdׁׁ ߁>Mgǁǁ9OH߁w߀> 2481,170 33>3oursSurvivedOatbyЇρπ24138ׁ92ρ djWhitealjχχρχ9߀8ǀ325φπVOOJBW??39363ׁljljLJ'54׀76>About 2ay?ggf/6705742 50inute/-1Zׇׁ׀ְ,10ׁחG4">D͇41,63W6Lesshan''ǀ_2,235O''?߀2߀,485'LJLJLJLJǁǁLJg,29ǁ9gǁ_',20Gυπ''2,449Wv½''/tbodyqable@divh44"d="pgepubid0003a6LK8ɁHEERITONEALAVITY. InumberfxperimentsaffeinasntroducedYohePtonealXvity. Rabbi؂PdirHarietieseceivingdAoarrroXwmployhfthis purpose;odndtzgive@dium.ԅminimumquirto inYymptomuseeathxaaldeed;esYih4 "hoadenouPrordstudy"influenhXag€resista risubulashownllow)os:SAh/Flar++dsped,pprox@t0.3ramilo؃G"iH"> 71.raye؏`Weight, 1,659sigǂI">January 20: 2.20.., 25cqueouPoluti2ŒY(300g)Sinject~; 3.45whdoorcaJope ;(Xsm)rturonWJ21:҂fHdd'''#KooLo2lhit402σׂM11.17ፌ0.2()QǍǍ ƍ|romurett@(paraly30 čonvuls1Zpick`upäl, by ve a#tyX0teu2oonaߋ N߁K8O6@BlackO2,14+σǃǂ8P19: 40Qh4,>0???:about 7`; removholx ep)violvs© к*Q8RBWWS">obѾKWPas!~گmumethXq;h2P 0.15ʚzרmfTo/U/9/714/߂ςV/q1$6b.oymptom؝obv2r utedefec9P@opil8нsoftυυυυϚxϚDž,υυυɝh˦*40,  5 restleseflexescrease 90K910϶˓8729pCX?9T (ɜx 2.2w33ARi&iOgge4">Febr: o5">Autopsy1:irrhoXi;its`lYpsHach kidneysr@/+6߁7K9793.ale,푟19ǃς8">March 212X2כovleXgXl occurred,ع5ttackspPclonicnHithrigidHpos0extP`dur9Iճwe@intervals,nteriorxtremitiesereelaxeduring theivalsetweenattack`opisthotonosfhicalXgionutyphosis` lumbarobsed,oalivatndilat{pupils; 2.., rabbitPed.

R92.ellowemale.eight, 1,388ramsi>ςǃςB">February 25, 4.15$ 14cerntaffein (0.2:kilo)0ject0o iecavity;20restlessn ȁcreasreflexe(foustched o cage,JraihimselfnXseggain4gener(whouWWSCW 26: 9lG ead. ggWD">Autopsy):Ȅrhbdominal musc@itfD;ǘPowal8stomachPp(simr spo.E'K9F&309.elgiaparPge500dieoatDŽoog9G">Mar2: 2.0wvsolub2.2ye@bladder_H__K9I_07___؊___godJ_ 12on,obtfrom ,hepambYolorAutopsy:iverngorged;pleenongested,ut not la#kidneys,ome]ionrtex@tomachill1mucosahickened andasilyu!ff;etechialemorrhaner oflon.

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Oration܁oad(neiureteffectfaXwhejinto peritonealPvity.ԂHshAfollowiaabledicateXstimulng nHnsec8hrtetpishoaorrrotyur somabbiH،moderPm`!fugXaftpfrom 0.2815ramn9iloasiven;bumVXpse,utnhoIn ;o. 311{Ixf0efo0ˉ  : which:cthreeoursƁ@OLenX7C6">E߃?=Hi>kdivsmoC8"[2data-summary="qrbodyws0t1hGp1tdׁׁ ߁߁ځׁׁ">cc)Oƀowo%> 307 1,320 04.5/>Ϧ$7瀷308305 ߁8d4">D͆29,2.wT20inuw>ô$???=3π?6??> 9ǔ25_/q1ߦ8C—Tamh,bontrolabbits,a81h,aribetween 35nd 50c,xxverage:nimal(glittaboveB0*ԁpF QxaCasuchessorequ(iodʵp0KCBpgepubid00039"Pp="[Pg 33]CCaP_33ggdD`/a "centerwCEooCFؑ 3G">IatonehinjecQ?xmlers="1.0"ncod="UTF-8"?8ht8Xnxhttp://www.w3.org/1999/x!"aen"> SERIES.(r???NoԀ>eightCaffeinerilo__\TimefppearancrsymptomsnDurationlife3ReXks{d9"/8hi15">GramIiAdׁׁ ߁߁ځׁׄ__7w7771π1,659 0.3  //C>85inutes//,24ourω*yAЇ62,143 ''OAthendYinjecO>Black-2/40''"''"1.25*'"`whit___4gg,ROUPɂ0w487׀π>10py_???DŽ9,49ǁ2''(''.'_">Male;ivenecodoseft(3:,ied fa׈׃׀}׈ׁׁ''bout WWSSurvd>W?'?ׅG 71,388??''' Yellow/30W,50''0߁gelgian;atswOOOOW,35_.153 4'WtҨOoo瀷7,32g߁W gg>o???C????t22w,165W12ϨχoarroGGG71,60?1''8d-,2''/,5''> 2981,205 .129">1.5ours''!8 do.nbr4D/tr> SERIESĂ????310880.2  //2aysBelgian;atsGG_GF 65G7?''@/Survivedא_274''40inute/.'MaleWWWgY59O57 5/////'!YellowndhitooooGj4o''w?Gray/Of9''߅߅߅߀O3׀25F2 2ggǁG23f225_?ggsWg`/tbodyqableenter"id="7K4G3(ߴ߁GxOHɁM@h4W18GW-fedabbits,checeAietxcluslyfXeres0forh experims.henjectionsmadumbarrgl aluscleQpO6pInis4aṡׅׅ׃???B"i5GC">R 284.rown,emale.eight, 1,100ram ig/D">Dmbe04:p..`1cyȋ (0.22kilo),ndhobvatil 5ha`requjonvuls;t 4comatosondia.҉Cfo`enextorningEF86teblack3''G.303όόόόό1977tres*increareflexdur(two ,pnorymptoz___XH_ 17:MPveI1"itle="[Pg 34]GJnPage_3ggbKk4GLǁM85,Howϒ38'7$NǞ15$''''' gener(L~?7fs.

December 17:abbittilllive.

287.elgianare,emale.eight, 1,140ramsi>R? 15: 2.15..x1cf 2centaffeinnjectedHtohelutealuscles; 2.30]tonicontractionsposteriorimbs.aralysisndeath.RerGSsp smcapGT">Ses‚`Q///U">IṅrEwasgflumbar]V"WWH0V30WWWS75W/1">February 16:.058Q??(0.1362kilo) nd(obva 4noymptompallowed 8walknzfloor;fhinghortistanc oschdinAp extremit; 5.2nfod׊NJNJ24H306ώώώ86σ4ώ̎12.5ώώϖ12(on_ZX9about 10Heexhau ׋; 3ˊ54H6181銯1,2X (WeximdQsome treviously.)/'/"7 0.5׌ ;njnjƀ,(onZjetC?GGA:"HYasayeaddon(serr@pwidoses rangifrom00H 28milli5hichӏOL Oԅ0resulhive [obviaaprotocols:LjLjLjB7C642577h ,5/ςςD9ptemb27Җ7牟~reflexHincreaseττEτ8:҇norxF">Octo5:O,6%.5___[?;3WWWGGGHGG13Oo0WWU(131g 1φmu؆////*H/14:l_X///+I_/4HJ/2GGG PwwKs7WW᭑ޘw'τττLϘwwMw't^9χχχ̇ ooOO???:N?oBИooWl42oooooφOASeptember 28:abbitormal.

Octo5:eight, 1,850rams; 3..1.5c 2xcentaffeinnjectedHto lumbaruscle.10-reflexesPcreased???;U?13G@3F10.40d4WWP(153g kilo)11noymptoj1.ЀԆ V14ށHveohgggbI0"> 453.elgianarh`e.,16i>2_12:45_queousolutioOOo; 4.1ΒOparalyzg 3sppgepubid00042"itle="[Pg 35]I4aPage_3ggb5`/a 169efoundead. 7">Autopsy1:astricpcosaemorrhagic;쓨r darkenIothorgansw8?4I9?55?;ye|857?3A{'heg 4矏4IBLwA1,07omfpoisoning 򤏫x'''''@ Djumphoffbtabl@hadttackonvulssipߐ?WICߔFinds sameo.bςςzD4IE28'6 //'FP^14.8ooY0.18*w/__[G_6街Hgg4IIg29gW71,37Jߊ7P3752/// 7770K78NׂerIL} smcapIM">SeriD`N">Furexhimsk:b rygPeal, were(dethip7O"P~577.Ǜh75877QPebruaryC`//ǚ?;P ride;@ssبwalkabou45ppar,traw-colorurin04llowto qfPacrossroom` 20e looti؃Retchimselfhon"f`pXni95GshowdisturbancegaitggcRg 19-???;SǁO4ITO7 I egļ-gσςUc.0no`ϔϔ˥}Yϔ5Г ,⌐notv; ߑߑ,symptomPbvV/J0oo4J1o7(Whit+o1,492Wp(cagȢގOUntaken fndllowedoalkcrossheoom,opecialymptomsticed.

February 23:tilllive4">Rabbit 580.rayale.eight, 1,510ramsi>6 14: 3.35..x5c 2erentaffeinolutionnjectinlumbar muscle7,oodondiy8774J97814feGC68GGǂAWD4G7GGGGCgafCide; 4reflex(increased.jumpof#table andadilvulsPs,ecameePrest(about Xratoryq25 tccaQallR30extremЅ؀`end quitbid; VsJdeathB4JC82琧87Dx8; ސ0Pn A95JshorpasmHndlEA;OOOJF">TxdataPpse؊ imswatoxicityQ1 ߊ݊WrPgbi3sasS'$ geԋ)s8Ace`xppr mately 0.2f kilobtwoiult{@toxrsurvZb 0awerbHߌߌߌG">IBldosfl,ro!ichtoue8s mo8__WFurjhe8, faicorroʃBbtainyuP+CئX150<Єhpgepubid00043"i="[Pg 36]JHHaPage_36ggdI`/a 1> mgG;ducmY%nly. EXthrgy0.1'%mpcause ɏQbeoti,Așo. 455a* ΃.ewυтefcarps amou)@ppALwڠanHl\0ϕ|Aۃ WOs, on ( 581)3ҡaftߐ; ɤ r8Ԁx$threz6K fо:Post-(temamin>d#cY(bnorX7`bsorpj lsee8be꒓ZHr9diremucȫ/zAu Meltzer8f="k8le:pos:fid:002O:offH800175wJJpsuws22JK">7pupif(sػn. Acdingir8vpig adrenhrapidًib\__!PxbabixyuɁdelXc*YHymploy(sijudgybecʆloodz(e)Ze@) v substaP׍derOJLaف smcapJM">Table 4X—SERIES`thhtr???6">Ӏ>eight.</th>Caffeinerilo<__[Symptomsfter—ggdDurationfife.ggditeIinjecwtnbr3HRemarks/tr> GramIiAdׁׁ ߁߁ځׁׄ__Xw%> 28471,100 0.200 ''%3oursLesshan 20oooGluteal'>WhandrownlJ`_286?315 .1977SurviveddowslackwwwwGsow,3gPresentoog`YellowjwooooOWjπo,14ׁo21o>15in`/-2///yOOOO4"olspan="SERIES‚????50,17W.13o5_6,1wwLumbarNJNJLjO0,86134π>ĀՇׁ׀18123ׁ1ǁg׀ߏ؇ׇׁ׉ggC???? 2_,52g//ǂLJπ,401423//ϡϡψ742W,8.153//LJχχρχɅǀDz.20χρ//*Lesshan)/o???y/g'gg45'g,18ggׅ׀7286518/o'29׀340 .200 10inutes//,Lesshan 18ourooGlxal">GrayaleG8׀6721oo_94915//*Survived">Whitendggggc_1,5g߁Lumbar?1׀6/-5?//7ׇ28.194///tbodyqable@divp18"id8K4JP">ExaHationfԁ 4howt 14abbitsecerom0o gaffein perilo.hppearancesymptomsnesevariconsidely.n somepcreasreflexesHuldeoticЂ@xfthHjec$ T;ortaselayh2r 38tghtyadd‚xetoccurrmanysXveryoadHistrdrug—on aagXbouP 3gSed.s(ler dower'`xyOP`l2usclґ炐el#iRjdulif!14 Ej{m with0;ix$. A"0.2m𘄐pyregar)hamumatx,hile mxicsbwetweeАY1gp(h47ۏАok5JSINTRAVENOUS_INJECTIONWJTہ?SɁ=h4'''4JU">xeximencar򊹎@well-fed,uPgrownێtiet fdaysding_Q@faotsRch{g8dppum{mad0i詒aurettrqmeans artemath}solubpg40°ßn YalsoxІ񄕂8cЄaf7*on Jit8)Ale {de(ӳ!*followysܑ瀨erJVЦ smcapK0hA`҂1">IMw[wu:c2iڭۆWWS2"i74K3">R 194.hitfeexeA, 1,3Ȥi/σ߂4">Octob19:@ 7.59'm(1 )oh i.҅)YtiffnesplyYextremiti&.FNHhor_C_3'K5alass="fnanchor"ref="kindle:pos:fid:002Q:offH000M0"id="7K4K6">[C]abbit survived.

556.ray,emale.eight, 1,635ramsi>ςǃς9">January 31: 2..X1cyerentaffein (134gkilo)njectedHtoarH, haboutaminutes; 2.10%convulsions,rinhlyingntside;ur the8stf`hour0adnsccaQally; 3.2ρ7ndi0 didothateftXIKш''#A4KB57580ǃςC.30oA7]7??Ўfromburett@Bflow)liquceased,serengorg@@ bleelwwastbyeafyOOin0woWsskpped5 uaielftllver_PumnorXtitude,lked orittanifanyg YeHc(; 4Ydc,a@Jdi"seeɐbeooD">Febr nR,"P,(tmou@, 9ojsolu,rxOOOKE4KF589ǃςG3gn 8?J僙og, violr7ostchВ9hibdomehexmPes `end̗7,oo1;a gHwςςI//4KJ.292.elgia,_Y77__K 18:26(9 warmv (0.141nolHwht!quatyJ΄nic rigi`ymbsso5unchapLy, kv䎇L4KM943arrÛdays beЪxHiِ?N? 19:׏꟏(7 fРŞd8NarPr:ub3nA rep1.25wЇvrequ ack; 2׋udead.ԯt58b26 //.O">IxobservCAprecedsa0ymptomse8exica wsxaqsixdbrlywo se (Noh556) dxom__.ρowhichurv ahree` 100!}]an2)y 2ԈthΊ yregar1r ofcepy`wsistancu8erKR smcapKS">SHB`"T">D 162Ȋ employO ry#I1Yac,K Ev 254,( 10.8@ʙ`rodu7zseAU"V56xGrX6Dxa o/alibre18"id="7K4L0">February 1:njectionegant 3..,ed 10cx 12inutes; 3.01S toq93s,onvuls D14followed byiolentWns,arkopisthotono4.30rabbitied;htal quantityG 16.

R561.rayemale.eightp,450rams.ieoatsi>''311.40;j8Nstruggl7a2er caffe50狒;ぼmou& !5cmIHopp)esumYs dist`yreceiv4.5soluaX fdeadidotrinate, 2byeLheladder74774L57604'#62'''6'''11.?` 73wasOdgnextHreeO bu!ere)noᒞE[1nd I8φφtroducthisimeuaflexes\lcreas2xonetanicזoffnl Cpnma(dQetch9Ppabdome0ities `ended7 2: 9ς77738774L9759gGB875GGG'A">JanJ3@FGsft?ofp 4.08ڂ?7to @n2morИlyAl_*(19gkilo)W773Bq6dHgoowalqab,hXeppcc dped(h-brow0se 5&rePusaywwwsCǁ4LD27ŜIwhq3VE 24:X.0.rapi3tougularX0fvnt!twi`musclXlego!ymptomp23 (I6, 3ߒ/ub7hJ ǃ9a32灃D 듈itidanhiorχparalyz posAralo̎ae QlowthPnorxGi5dihadimiate0befth;hoisr 66:o__[Foo4LGo54.elgihage28wwDŽoofH">Novemb11(1/Xb_[w4LK">3Yb>z.47¾receivi0.fromخ0tex eL6.Zdyspnœa8.@ugglߘat 1.50½leaholderIsisspeciyH0shch,urvٳ _ 17Śz25ndx$_בL__4LM_55_[OK10OOO__VNOJ2.31(P5¼ϒL3r; 7'!O">1/6Yb>0mall>o 2.46pWSWW_w4LTWUp.., 5c injected;fter适ionf 6.1 onvulssollowedyyspnœa,hen9tinuous struggling;8.3Qwererabbitadno r_n;q7d toniJtraaniorxtremities@mount6,7(158g8kilo) 15텠tespd 35e0ds.

<7L8LUHi 5LV">R#567.raye(e.iet,atYiwK4M0">February 6:ɍVbegant 4.11;a8,؏  2cecaffei4.21htotal)84ŀ resumH2Ymotroduc8Ńws-;($ 1!`r 162lo40|paralyz؂(pos# ' 5f`dead1p`pgepubid00047"itle="[Pg 39]M2aPage_39ggd3`/aQ04">InightPim`smpris(r‰$sos., 254(79,355, whichhbesignaYasoIIpeceivdosؑP`60)6{,Ipvely.p5605q550yabout 200͐.́މer ne (N)urvQ.hisr`rdexcepIal,ince@sahowیApAd,v8fa. AbloتefZ,st]Zbe@oadiނilbtainX@UYbȀwiȂ`i"casisp eHmark#g؉s z294 ( @@onnӌ|y ahder direITۨaithany偐ctPztoxicity. QgrePHitaZop1obabildu0cs\ǡ4erM5 smcapM6">SC`ςρ7͎osimumʏdeȀ}Ax w ameqיהoOOK8"7796293.elgixh8|W,610am''wwgA' 18: 3@34warmsolu˺ 8o eariȻ7h3y rep ttackrai(elf Hleg feomilPstchabdoB 19: 9ᾇlooorPpЪ q???:C8??D?27hi`2,32폏E">Octob2629¼37½wppfrom86.7 ,ymptom0sinued;oFWW4MGV56GrGF5GG''H IbH.0x3.5G(42 )fouriut 0.6mXnextwoBone-halfto amouhF4.1`;(h,hysensvs1turbmuscular coordina;9tsn 35.~eflexde,rўwalab, ga[.nHЪhvRsealayhs`I4MJ64515oǂKat 1.26 p.., 3.5c 2erentaffein (46gkilo) injectedtheatef 1 9minute; 1.30reflexesncreased4 markparesisyextremitiesabbittchhoutnbdomen,egsqu anztly9ended,leoop` b gadisturb1nontowardymptoms noticuXrbservatiforeveralay(ftexpit.

R565.rayemale.eight, 1,545rams.ieoatsi>''N">February 6:tH3.4eceiv2intravenouslywo8r 32loallnoo0no O4MP66900eQIZbega053three1edυυR">ThesAUshowao`[50loheilpro8pmil',uch7d.fou߄ withСamoehcwerx axc@ τ) isplquantt؇o gȍ[w8manifestӅH^s8Xwsmay,ore, bȑrѐimumxxics''̛TcondonؐerMSsp smcapMT">S@D`QOU">A 0XDsoluAuoo8onЁrity;oXߛ*ggcV"ϣρN069̣47wwDŽ1ǣ11.a112.0110Y''3 1ȁ߁߉1326spgepubid0004ple="[Pg 40]N2aPage_40ggd3`/a R WWV0otHl ccB20,)‚Xurine; 3,(vulsq; 4;ד/4:l,ooOOOL57o4N6o747z55''7o 8x0.250.33ÑЎalt,8distH0`扠p81.1R W!5yensve;marked8 9GGF94NA71('Bg 7:3.13332-,*hyW 5s ssn ndakj`extrem ؏urol!aQior ompairctparetHt`d!walkboudsame afnoonggcC4ND68wp60wwwEwwq5C1 DZ73gasumwoval14 venous11ςA6Md3ڃ2  K 1a:blyi`UZdeathwFlpr. Autopshowgestion ofiscera,utotheresions.

Rabbit 570.rayemale.eight, 1,225rams.ieoati>''H">February 7: 2.06o@35..,njected 24.5c 08pXcentaffein,eflexescreased convul,arsspeciallyarkinhenteriorxtremities; 3t pXhurinehichas8r!appearancetǍrˁ weakggcIg 9:oundead. GGJ">Autopsy:iver,pleea8kidneysagesp;arge ixsthsemorrhagic;mum:showXAp@e0flXseous nodu8Aadhڏdiaphragm;5|A*.!raabdomin*fX犯K">Offpsth8s`threeAssult3pdis(. Ttwosurv`vmil`ymptomnlyuHXe,evidePoisoningob0af؅l samos`y Ae 2solu. C @icco (No. 568);!s8 9571).ԆHnВHgroup, or2m鋱er thaG@ ag th,pʇ)gs CII׉Osouim.ɡPsuit!obable1tXeXh(tuosudv0\bloo[1di mimport8actHJт1toxicityn͇ivjusuffje!:mxcau8aly alpdxorgarNLsp smcapNM">S[E`Q?77N">IexnOO!؀/possiifluڋ71h&ϸȌOf 1|ٜ-halВѧu@__[O"P">R572.r@e.eA, 1,770amDieoatiw QO 8:ɋFbet~su.37YIm 8;stpxfyh5otquAreQed, 17.4!馠(pt;quggl8mittdur;(ilegsz؊R 9:ouST7381UStI1.352.2ȍ 18 -rked soH;45,sɭye; 4.30v.;ﷁV9?777K4O0(illQobQ2so red^onsetiy sla,,u hlKa8`wh0Ȁadepgepubid00049"XP="[Pg 41]O1aPage_41ggd2`/a morapihle,IXHYhauch\ ɣ Hside`77ٍ煲3romewbmipJh㞠app Ęximuhao𪬃a_׶e, MOLbo50gkiloXwichducHsev1nyqfa; 16WPyure %hdiُww9)se@is notarkednlesshenjectionsreerylow.ilufRcaffeinosuppr@es tomextentznervousymptoms,utoxicity,nontrarseemrbcreased.

Table 5XI>—Iven)7i>divtabO7"/)2(data-summ="qrbodyws0tr1hnbr3" lу">SERIES`thhtr???NoԀ>eightC\perilo__\S'%DuraUlifeggDie' >ekeǂ7d9"/8hWV>Graitdׁׁ ߁>MgǁDŽOOH߁w߀%> 194 1,3101P@SurvivedOats>Whitel?556635310inute/-2///d5y////+7/58777777r ĀՇρπ55859ρ0292774152//+Carro/߇߇߇߇߸olspan="SERIES,ROUPɹO_}6W,6_2½our''O7煷,4ǁWWW56WW,62WWGGLesshan 24oo59875wGGOOOOHW?V7?7,3W16>1ǁljandhiteO7?5W,28">SurvivedOatsnbr">Grayemale. /tr> 567/162AAbout 45inute_X4Do'''t255g' 158'Di_2hwr3"olspan="SERIESÈh???93_,6100UPresentSurvi߁߀ߗߐ2߀,327None8dOWhite퇇56,65gg7瀷451'46߅߀gooWWWOW,547WW69ρ3?D??π947_ǀW'ׅ,5512ϏπŀǨgχς?π153ǁAbout 2ourׁG??χ߇߇߁860߀O">20inute/O'7,22">Lesshan ooooǁ7777ũ7??G,727747OOg2!573o8O/tbodyqable@divpoj18"idK4O. TheesultsfxexperimennabbiXshowonsideleariati intoxicity Tsing@dose.ndividualsifferedolyirqistancixrug thatam/)hadYbQpeatmanysthachethod9admin0r befortisfactoryQcluss`ulddrawn.Ԅik!y ilhts venounjecwhia:near0.2 gramerilPasotatal.imilar{ excepalWrseti(ess ca@hbservwhetgq1orys.mpsdA=Znt\IinvestigYell-markՇ1@ty,lhughAyX1quito6 xs alkaloiȒPorisevl rwێ@*Kdic@s8rs v2ndea쌔mouth[Bmum twooducGab 7.1;elkof`?r끷3.1/ubcueXs 15920c9rQA twe muscu1Ϝ'!s傱m)ԘZ"@lmidhced )toP0pes0hali\ .eltzAuer,href="`dle:pos:fid:002P:offHxpDIOEsu7322OF">5881϶Trgot,ˈ*kfroh obtainS߅߅߅ߐI߅߅߁J߅ڭKusAIsiblȐ"0ult$mh 吁Ƀbehavi: vЛqعմEregarAppXsrobaudO4H)bsorK )h?9Ach,aQ YRib(Ct. nSoc.iol., 1907, 62: 90)l cpco؛Yoluiz"olee smallׁwOK{ik. T%tissuunequH8ڀoﺂ .iLM wverytrigVGҷurarahd`n;s(mewAǑph񀊬.h4`tocolȭsensyom f56 shZvariouubnceshaveifferxly+ regard.hus toxicitystrychnin,$s,щthsrewheniv0cueHly  moudixDminimumatalovein. mayremarkedowever,+exaatiȂ9dH"Dre muchoargeor2rabbitpnXorrugs0ttlrp.ce betwewodId #w@iceL,0gi؍0but sbmoct`1W,Hity @emet:chlor@jussamechP-hodintroducingFڤ8(D.5ǖߘalsop0observ1䊿Yn, r ?fwnequal.

T1EXPERIMENTS_ON_GUINEA_PIGSOU;gSNǁbЁ`h3ХW,87OV">Tcastudi(xanumb adivid sqets confull-g`:KarrA بeasons!yYjewaySpeci attȝuІ8؃ossible finflux8Hs"T,>eߒ߃ a!e(at`RYoqʯce(d b0yr.Í_Ӌpp_@Qtal !4O4P0SUBCUTANEOUS_INJECTIONggP1sOUSɁMQ4WerP2 smcapP3">SHAhʆ4">Preli!ryؔx9guiigb 360, 300k290gwnkilo)sA id@ 8d(seiz0vuls(lбourfZmՅ5៊durBttackkhaxe x utinjH.epeaqllowedua ld Iaپ؁r+Z tmXᛴbsiderabunP 0.3ram׾#?this pyslp?!Hul@a򇌔/nexI\O5OOP6NBOOO7">EǓ32ciistitpi'''P8"i5P9">G 20.ee.eight, 497D 9April 2: 5cf-7311.30..; 1.50a, (s@ru Y 3T4ne-̚wwsBHwwCwp38.¼⊗570.8ekreviX ?υ__VD">Febru!11: 3 6OOOOLb (21); 4.15,flexincreas馁_] durbedY45hhlxRparalysis;؁̲s lyiQQspidifficblabd/׊="7K4PE">February 11: 5.05..,uineaigoundead, 2oursတ15inutexfter injection.

G/37.ale.eight, 820rams.iecarrotoaHduringeekrecedx theUfffeii>τDžτH3.38.5c0perent탔edubcutaneouslyhe back; Fvesensitive, iorxtremparalyzwhenle@frequ spasms9pos ,oympto0noti0eforealtgh watchallimeǑgiseglooknormal.ott IɌ׌ I 12: 9O;iith18J4PK 13.e 6πiL">March 29: 2.45(0.194 kilo)M30:Ht 425q'ׂׂׂN4POq6wt5vFenvih to?__WP0oooto3somewhm1anorepctngٞwwggdQg__about.???4PR">Tpresul`hseH@ntabserv(fwindicatBt twoci;?ڗanihoducXMa0lhP!a񈘇9neath(llow{مws 70<Xpgepubid0005title="[Pg 44]PShaPage_44ggdT`/a 1>1)firs``festaNԅj̴nwhile ldg?o.v2W ?S(C`__Q0"WW1WP6PYedarkr, 512">Octob4:@n2{=) qɸ!3'OO35?q;oXgood49:ƭv. 5">Autopsy:ongq`kidneys8l11ne'#6g/4Q750hiblwowj8WQ9,OOOQAρ4QBϋ0dye׋32׋׋ׄvC3: 2. 3.GGE19WWWV T;40 vulsYcoy156frequ sms[paraly ,splaiortremes.3teu@hen d(og3p0floor''#D'8f'QEstionfmallntestines,ungs, liver.

Guaig 57.hitendraye(eeight, 350ms.ieoatsXi>wrH">October 3: 2.15...5c 2centaffeinjectedubcutaneouslyheack (0.2kilo);40convulssitheco y; 5.3>noarked sympto0I4: 8.ahve8ct@___[J_6:ou8deadt 9 K">Autopsy:ong;`dneys petechiaH;eeastro-heritigL4QM68.ellowȓ?, 785???'/%N7011.357.8GGh'&; 12`on,@flexesXcreas`0 4.2ށNsamHtU熿O7:},ߋ4QPLBᏙzfatt`spleen,howXhemorrhagicpots;ӀxmucosaecroticЦ porPfldQg4QRga9_Y5___''S[5__ ,utthA`No.0gghysensXϕean)߇߇߇TߔU15槶7773V//4R0/)1.rowh(bl|144__2mgOw?;uns3drapopriorxtreme'2ߌ߂GGGR3߁4R4ߌ2,`''$''τσ5!.05???938???< hb; Ʃvuls5_ύalnaHgith paralysisYaBx6GGGR74R870펢:4wwn9`36.5quoluP03OOJ{A9׌///,B4RC׃(wOXowlDE (0.24ʌw @4tehu_E777//-F0sp耉pgepubid00056"itle="[Pg 45]RGaPage_4ggbH`/a 1WIǁ4RJǐǐǐ56ǐǐDŽwwnK/ǐǐǜ֐x32admini)by/18PoRL10:d. GGM">Autopsya:o70,X 2howgesZofrgans.

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' 4Do1ρ166π2Noneρ,ǁ 4׀2d'oooi3o0?3o4gggggg24'g 2w1/Ǐ5176">Reflexesχςπχȃ,049׀χϗsedt 1..,ithoutavinghownyymptomstherhanlj/tbodyqable>Theubjectssin esexpmXsabbihofediumize(dapparxly you0or!)rate+noteryld.ԃwaslann fЄ(tudy ipossiffx9die@oxicitfaHwheniv0som@, eea%`sut4cotshichdhyVreviouorks alreadt0C}sbyxh%usualy,P)lution, 100pkiloaily.ourtBZ<`testszirighL recordhzjobvasadtrequivalsuraday3onPcHgickall邁zthisG@rogrexve쐸Dsfrom 3 8sfadministЇ@drugbegun. q8&lifeaHide9No. 382>firstse9 ld X,6,@5, 5;o. 390ived 7aysndo. 404 20fterhedministrationfaffeinasegun.ԁHdulifenll )o(rsfrom 11o 16jfindingtutopsyr1Pestsuggyve pregardsRpossiblexplannectsyrepeat`dosag.night rabbieinvolvementmucousembranstomachr"es pb.incecameoeao-alH1Aobser 0previeri`ith_hen0j subcutXly,+ pangtuboi郂lyotcausԁVatal outco8dufore,ӎԅabovȇnbrouЀuty .̓Pr relohcarriȂ hЌwayalcoholxrvtrxhonger. OVHs,>oftubbcaɂ׊׊n%1nHdiet.҆w1fIapexclus PePmonthlorthrۓse1xpneuiaş miex ccidalitA oivatho)r two!`nۉЄ`No 382389,8ulddis+lutoiul xנՖ9lar(dthof*xc؅ш;,di靝doȐ)umulbodhZoxicity_XV _Zpz,<؀pP_70ggd5`/a 1>aRrroyI:Malshowmq *7.(t8l̂xbuPؠ7view he0Goure8ch.h`="kle::fid:002O:offH 0052E_N6Xsupl=" ibre22N7">28`upp> <18N8i 5N9">6. A">Belgifemale_τ_B">Gn 1c1YYգe100ram8idivsmtabwNC"@hd@-summary="qryws0t01Ēxth WeiT774/ǁnbr3/trوust 20:ounead 9..NEtopsy:ungl!lponges;ngorged riI;ally(wePfixd,F5NG89Hlack??IvJ焧w瀷瀷߫߁߁77瀿eight.</th>reatment.< /tr> GramsPiId߁߁߀ccǁǁDŽW777O4灜G9Aug. 1771,0700./18ׁ025v/tbodyqable@divplj8"id="9H5NK">0ust 19:oundead 9..NLtopsy:ungseverelyongestedpartially hepatized;i`asngorgothhansppearnormal`p5NMhN">Rabbit 382GNO">Belgiane0e_τ_P">OnI7eighh35痉;ece8cf@pcaffeiorach0 10gnnlOOLQO8OONROO stomshowYumeroustechmorrhanucosa;idneys sltintPin//NS/5NT/85/U///τ_V؎z,h(gtub؃smwO0"hdata-summary="qrɁws@OOF6xDatO W]775yo_W_ggρ߁߁߁߹ǁW7O߾oGo78_8WWǃ2ׁ1GOA7?LJ8ρ6.LJ1ׁ0LJLJ9ρ5r2Y{/jq@Xo5O22ggO2xhipneumonicesions, wiinflaXtadjapleuraho-ptexueresAaXl; aHccidك8@2Wdi(ndX\ɽmembrane characteryѱY҆;قtfiquid Hnaturebi xlargeomewhatmpkidneys seemlyorww~hate.ǁ Weightnbr3Treatmen /tr> GramsPiId߁߁߀ccǁǁDŽW777O4灜G9Aug. 2071,4654./3߁,3wr 13.܇߇1ׁ47߁,3߇2ȓw5Sept. ////33ψ3ׁߐׁ31߇W4ׁ404 ,35߇g5//(H/ψט6ׁ4/ ׁאW7ׁߘ. ,38߇߇8/ǁ,329ׁ31 8ׁ3/tbodyqableenter"id="9H5OBxOCoted.  33///5ODeflexes.ember 9:oundead 9.. Autopsy:othungshowedxtensiveneumonia, wi8adhesionsoleura;CitisPpericardveryarked;argemt ofousxudatenlavityyloxȁstomachlightlyongestr thorgaxnormal<G0H">Rabbit 393i>OI">Belgianr''J">Gxn 1c1㕐ffeXea100rams,hg ate. GramsPiId߁߁߀ccǁǁDŽW777O4灜G9Aug. 177950.52ׁ83OX 8LJ8ρ1.LJ6ׁ78χԇLJ9ρF9GLJǁ6LJ7ǃ8September 1:oundea:ungsongested@adheringoheleura; extensivenflammaJofrlightlynlarg&;ucosa stomach smallt0inesGrrgansr68PLjǁRabbit 390i>O6A">Belgian,aleWDŽWB">G0n 1c1affeine100rams8roughtubqxsmg6C"!9{Pdata-su0ry="qrws0__hatth WeсTreatm7741>eight. GramsPiId߁߁߀ccǁǁDŽW777O4灜G9Aug. 1771,4905./21ׁ265v 12.܇߇8ׁ374߇2pȐ€7 9G313 O23ׁ12o1߃ۂׁ,34 j2o/tbodyqablewer"id="AFM6Dww6Eoted9div86F">ust 24:oundead 9..6Gtopsy9:eart(lungsppedormal; abdominaliscerahow i`ntathologichangetherhoccidiinfection ofeiv0fullnessbloodel1pdžψM6Hpxpgepubid0009(title="[Pg 72]6IaPage_72ggdJ`/a 18KggL">Rabbit 3926M">Maltese,elgׄgN`n 1c!1Еaffeinoach 100HroughtomtubqPsmg6O"AA`data-summary="qrwsh6XDatth WeightTreatm7749_3檏WgȒ>G/߀ccǁǁDŽW777OG灜GK72O12O߸v6ׁ1wwM߇8ׁ27ׇ߇9ׁ2߁28ug. 221 1,020 nbr10./tr> Diedt 3..*ember 2. Autopsy:hetomachndmall醘stineshowed numerou hemorrhagicpots;hickoagfucurndtpconts ;jo(rrganserepparlyorR''76T??U">Rabbit 403ipV">Blackb7hGiven 1ca1Бiaffeinor100rams0sm7H!pdata-summary="qrсwsh6`Dateth WeightTreatm774?3楗W)>GlY'/߀ccǁǁDŽW777O⁷篧o,646?߃6ׁ3w4W߃ٯxׁ߁7ׁ33߃2OOطǁw7087777ɀgg733G?415O29ׁ1o1߃4ׁ51ǁކ1,05߇0߇ׁ,472/tbodyqable'@er"id="AFM72''7(oted`div87ust 31:oundeadတ..7Autopsy :xtensiveastroitis;쀰r enlarge`congested;pleenlightly;oneumhicken 'therrgansormal:"id="AFM76">Rabbit 884. 8">Black,emale

Given 1cf@perentaffeinorach 100ramshroughtomtubydivsmtabo7A"le2Xdata-summary="qrbodyws0t(1hXatth WeightTreatm774/ǁnbr3/trوyember 2:oundeadt 9.. Autopsy:heosaftomachhowed numeroxhemorrhagicpots;firstorقsmallstinesaslightly Pgedo(rrganHerepparlyor`XearancerGG'7G1pan逈pgepubid00099"itle="[Pg 73]7HaPage_73ggdI`/a 18JK">Rabbit 383 i>G7L">Belgiafe8igׄgM">Given 1c1 aaffefeI100ramspPgؑtubm؃sm(o7N" hdata-summary="data"> ate.؈ GramsPiId߁߁߀ccǁǁDŽW777O4灜G9Aug. 16799510.022ust 28:oundeadt 9.hWVRtopsy:ungs,eart,ႀspleenpparly normal;ivernfectedithoccidia;tomachywallsfxl istineshjj;Hlonarkconghemorrhagic;idneysi1p߇ωM7S؈׈ׁT">Rabbit 387Š_7U">Belgiale\OOV">GHn 1c1aaffeinori100ramshrough>tubyȃsm(o8xPdata-sumy="qrqws@ǟǀ 6Datth WeightTreatm774 3ׂW׀8π5/߀cǁW7O4灜G'"1'&1,2672߹ׁ1w ߇8ׁ343߹׋5܇߇9ׁ33߁81 ug. 20G71,303.O29ׁ115n 11߃ۋ ׁ2߁3ׁ,13߇܇߇2<Ȁ7,17 2߈ 3ׁ20߁Sept. ,05ׇ04ׁ22ρ9LJ9?7,282mZ2_/tbodyqableenter"id="AFM8םׁ826oted.Autopsy:tomachsmallXstineshowedumerous hemorrhagicpots;hickoagfucuurndthents s; bladd wasreatlyishwithr`Ie(rrganserepparly nor"'85//6">Rabbit 388i>8(BelgianaleOO8">Given 1c1qaffeinr100ams,`gh=ub胕sm@w8pؕل#Xdata-summary="qrwshPatth WeightTm774рH 'W'Ȓ>G /߀ccǁǁDŽW777O77177080ǁǀߵ3ׁ02߈wك߇8ׁ111߇4ׁ919ׁ151.߁߇ׁ6χ9ǃÂρ,136ׁ0χ7ǃ1ρ1ׁ2_87gd> ug. 221@ust 29,oundead 9.Pi58Dtopsy:eart(lungsormal;iverkidneys engorged;tomachfistineshowedatarrhalflammation,hougt seexpleenvwallsfolonomewhat@ject`Y//78E)pan逈pgepubid00108title="[Pg 74]8FaPage_74ggdG`/a 18HόρI">Rabbit 391 i>W8J">Belgianr''K">Gn 1c1(ffeinoXramsrtube$xsm؃g8L"qK d-sury="qr!wsȤWWh6 Datth WeightTreatm774i3gWg/Ȓoo>G/߀ccǁǁDŽW777O灜GD17940.54ׁ80ψOX 8.8ρ5ׁ0LJ9ρ6ׁ76χ7ÊO3ǀ7(ust 30,oundead 9..Ϸρ8QtopsyI:eartnjected;ungsormalpiverff slightlyithccidii;tomachԂppancetestine , but@lonYsXr`yPflamkidneysengorgothhan:8R`S">Rabbit 402i>8T">Black eOOU">Gn 1cf@p㋡(to効100ramsHsm8V"їdata-summary="qrIws"calibre21">ate. GramsPiId߁߁߀ccǁǁDŽW777O4灜G9Aug. 2072,030./27ׁ1,765v 17.܇߃1ׁ95928Ȑ€73277777g709G?6ǐ6߃3ׁ95ކ1,545߇4ׁ909w߇,51߇܇߇,89߁Sept. ,4燷46ׁ788CҀ2/tbodyqableenter"id="AFM9𥯂09 otedqdiv/892">emberoundead 9..7793">Autopsy:heungsereadlyongested,he po`riorobefighthowi@hepatiz on;*livHwassidery enlargedvmucous ran~stomachsmallstines ;Xnumeryhemorrhagicpotskkidneys}sl \2QoXrrgansoroOM4Ipan smcap95QriesĂ`Q6">evXnc9forthprecedpa@egarcumulcaffein natur@yugs:qu#he t☁cquiraol؄Pt. Thishalr@yeen sdXityourewitch,28Kut CtoSodsPрtificOKʁfewxpmXs made舀hulaXYHclus.Rss A,,C 0qs drhawd9Babbt:i,蘐Vppntdostncs8؟ r dos(certaHdiscfoll:WRxA">R223xi>?9B">Belgihh,aleʄC">OctX2:e,p520ram15c 2nX5njec1subcut pD">Nov31: 10.30,@~17d usly (225 mgerilo),eflexesbserved,utoetanus.

Novemb4: 10.30..,eight 1,535rams; 19c 2Bcentaffeinnjected subcueouslyt 2.40; 4f,Qsymptom___\F_ 8:ׄ,4220(285)11.45LG 171,322d5, (329Ǐ„H 1RabbitoodonditiongggcI">224.elgihare,emale.ieHcarroti߂׃߂N">Octoŏ9Ȕ151+ qGGCO 1G1,780ǃ߃ߘ24ߞOLcreasmuscleremorsresNothwoooiPoo71o1.W{52x WQ2or 31w)F5wR/+%4358wq___[S_ 9rdiGGETM9U26.rayǝǝǂ}V270 ř?*.5?9ThesultfhximAdicathwhenfficit0s0lowxbetwetwuccess앨s,sceptibilityosQ.he K,htrarXseemsacquirehlerance@ydrug,vfourthose waslarg`8Kminimumatal dمx踨oba dupo*telixa/nd ducdecompos" Xrveryromelei(peacadeobbyongxvals^瑟6mbrieflymmup)st0@rX4 zgH;mai`N (too ) nhspx]tox, namelƇflex vuls?rhpihqxus show6cumul@vBevideq(undoub mm^jadd IsЁ͋瑂in؛:inuxaii XX@18y(Ym, xeڝ0althoughB8extonPAɣů8w*wu᠙Â񒉥arepairuronR͏dlopmecisYhX FermorЂjustlindicateshatheliminationfubximum dosHcaffeinndtsroducHdecomposi ibablyclished with24ourrreabouts.ԄlargerZnotςɂЀnterval)madeEeyfollowingxperiment:

Grayabbit 455.emale.iet,a wr9">Octob12:eigh1,185rams; 3.30..1.5c 2yȍinjectBtoBlumbaruscleaMreflex9ncsedxA13: 10|swed070noymptomhpoison, nnorP;ȇ0zy; xG$jumpofft,adonvulshs,dih3Lj23"鈸pgepubid00102_AB">7SNā0`h3'Ǎ'MAD">HavgainPsomefRrespȁ*prepeawc ؏IaBeshoiwrnivoraa"drughen؟ly ad)sYd.0`ogsreJur(CXidele vari :eoЂ0illpxr,agGGEE">SXdaalagenviron1(`y⥀(orsfluencoxicity,Dr8full-growKyouh0 foodJiqT`0Ikeptn@bsɊRp aeway 8ev`leksr^%abegupor( Pdeeaጙznyr0deɄzascert( -anoxЂ;Q0spC_iven chiyimh,XcutaneouЃ|Ho@oyur!a r ϘMlyiȡ {Pti!hich|dixrџividum`\alength .ɢn g(s؇mocxstil# cN.ig v(thucckyC*'#erAHؚ smcapAI PA`JxקӦisd ssDog 11.ePeiOς߁MȈric250ms;خ suga, crackЀab 10_Foȕ,*dJ0e1.5-BRi2S,p 玡0.213f͓ΝdSlowySymptoms H9xt.OOLцgќWka April 20:ՅQcid,ހb₏O1fre)om7777MAP62771 1ramhffeXgivenafnoonoookQn3: 9..,thirstyranklargeuantityw#rd notduceehl'solutiDŽDŽDŽR4: 2.30ۇׇэS5:cadisedgggcTf6:eight00.6iloscectMay exaeKabs,rh]vomi@ick,re s orȚ 500ct e,ppeeoo___\2[@pN;15?gggc3c8,Xdfpre2o by@uth0.3;Tnegat,ndi ФgooKsymptoȃintoxico߇߇4ۣPhabh dark-@ducilaginous֟d bottl]ihatrac(deedlhess,}nitpcept`lBmuscu-ˍ% (usual)5`񙷍/ߜϜσ???86;8?=/`ߔ'G ,jo腜τττ7˫8/P78ؽΔdeadzsinxxtsenb “ tanyl,ضaPn7f(toqs18 `18xys. :ost-HtemOHshow8xers wihhrhhcpotucosa;vYkidneyongesɍI; lung0thyroglibreat@eng4ϑC׈ׁD">D 28ɂEWW6.8diesi20ri!k 1p\0k@mealPt.ϩ(L7;. Heece.tX5 Hh.ԁ8nex@ay,4getill݈ough proP@E)U9A; ԇ 22.PleHlldogi>H">Ju`24:weigh13.7iloDietons؉0meexclus ly; byouth;arrheaeoped;HreeAs7773I587463.5"s10.WWWSJT30:7x|KylDž5; 20.1pA,uswell- thirstdidhtroduc8nyoj{LwwMBMt0.em9ׁςׁN">I1HW)7FЁeralHrbohydyePДric100 ;ugarS;crack l,Pfficiqua8tyolave fooφOExa@urialbuЄꅻgave neghveesultUc؅(Hmu7P77.4TѭfP+fĢ@cedX5:Ctest3ׄ; 5, aaP)p.Ʉill`ɏsecrea؅9dualpzaOYMn)urthk.̔`2Ssubptuqke4 /ctopXBI0AKe iгo@mg%.daizy؄d"neryY^. DeoccurhwG߃Be@dtav00 awܑ^0mpleȓor7nt:Q9:U11.45/WWWBRS2 0%_2____YS\1__12`on::,Qu???;TJuXMC8肇ǂǂ9ę_X6]'77772A4(7377777777B470.8/*@nk 5`cc;Ћ Qsz׃׃׃CԜ4׃׃Ӄ҄GGB GA77D`7K0; 4e8 ???;E">

June 8:eight, 7.5ilos; 0.9ramaffein, 450crine, 1..; 200Jseat, 58water.???:I<9?7.6??;΃Oer,?: andodust;iarrhearestlessn llfnoonJ10y77n 48 K18߃ߍ7OOO߃߃߃L27.71 M3:Gׂ3ׂׂׂN47.290 O5gggWgggdPe6f8.0e]W addedohecknQ7:continueR8.1.3wSDogeryhirstyranklif3H 3[؄q; 96dqgt 24ouׄT2n5׈iven!{Avulsionsdh.hisreceHtal21.1/+25se aeriod3aywhichmountsa؋ageA85gzilyU">Y19pi> oonD0">Femaleoxerrii_1">May6.4.ietsistric ;ugaيhsufficientuatycrackȀlɏlavoryQfood.xaminat ɔshowSXzalbu`utoې違waPci*mus. Twys‚jlkhyrsti@*8 ??__[2\(0byouncollec nextZresen煩abreducsubsta haremorCw,1refornodAxwwws3twws4207fy2.45=vomOq2ornWdeJxpOȚJeiCP'5120o߇߇ڇowI65; reۆ aos0.rewnorٴvphppe؆ (osymptokpoiso62:ߞgaFw b&oorhgH0ultdi#4Rfaiyh1w,η vnge2`six;io 3.쏈 4c!p, ;mak90ߏwwwr7GMD8ooj9">WhзbullWWA">TsepX0tclusеwjabbitu0FromJP0.6Ӌ˨Paiqse;9kcreasɄ)13@lorvalPN?ecty ~g ilose of 1.5ramased,heniarrheanoticedn theextay.nfollowingecorddetailsfzexperimentreiven:

ate. KilosPiId߁߁߀G߁߁߄oOOO'O4G_G9June 7712.50/16ׁ.ψo`8  8߁߆.51߁2.9.0߁߇e 21ׁ3.42狒0.363߇w燻燿߇Oiarrhea.July 2:`.30.., 2.0ramaffeinedyouth;؁Xp[tetanus,ogied. Theotal၈ntfOHtojNo.u t25ays}experim8as 14.45pornver578ger!,hich sabQ42a43d kilo)eightωωDI">Notwithsding(ersitynmethod oationhere strik)uniformsomQresulPobtain8ll?҉ses showabsencRcumulvecAn.ԂwAlvidpyd ipcatehatdte(larXdosmayeH0thXvalS24 hours0uc)anyymptomnouXyыXsturbaiss illu`dPn11w醰liminarzcharer.Ɂ邠subject 100150ɉ"xdaiXX!lˇ\ʇU.̅rcُ,f9j0r b,ildonl`suYremorjobserved.dditionalvidencef thebs|umulativcyaffeinasurnishedyresultsAyfollowing experiments:

Dog 23ced 142gnerilonpreeuccessdays.iseneral conHcatthatQsmouereoxic,utrvy.n anoreests,adftQaIo!tew*,agafail" showny㊡drug,swBHtȄwrIlonger dur[)irst.K">Auchetillustܑߑߑ߅d ܑnNo. 20Y ca@1001125} y,烸n`onsecuR{didotu(mark(e@ctDiarrhead yln ponlyymptomrTbgefolimin@ecomposapp8nt3body wi0w y-fouȀ(r abou؏WWWRL">E]19@ver,rm8cepy—Y rHo< vhavrofataleryXwtэt(iedis suggitselfaoblerista! xbj. B`itypnaHr/)20,hi`stoodh ƚzۈ p ara\lbuXurinrÚilikewipdmi z7В@lityn ڂb1)alk@neXg, geB1@*60uch`,,@bnN 3!llbabilqeawrndjsM">aargeumb87:Gr MlPohbeen ϋQdu s e(d`ذ7tYinuCu vomiǙbVincsC쏽.ׁpreCext no뤀.ӬzKs 11z23(lso ɕ.2`velopdntS;Osu9s`goie/s)אאҘ`rvoirritbyƐd Pȃ NiܹѡquiYhkgwHouleuD狷gsiArD 4. :150jPIfedʆSvhusu9n 24kwosomet)reтolap8be`cK0Q@dorP@2recAyrom?c >예tѪvѠummVeP si؊No(11,ك)193dopnoeemA ݃acut+مÁ(tght߰pti spck1Z%0yginnsl,ivh tofailuxRQmarkesolPa 21ҏutgiv40i60GIeZhq@,₰ё|p֡xtocol Wwwcer?DQ8B smcapDR">S` B`bS">AccȌtudAChnden,16owroteinietmxvesheeneral metabolismfbody,atiguesminished,nd ilyigor,xore,orrespondingly increased.Ԃexpectonׁjustifiedat:defense orga(mgainstleteriousubstancintroducXXoImuch5d byayPtsesiooisons.unt'srimentnis Pj(Hlsouyhittenden,@ppor`!vieweou(Bmice fcarbohydrat8chiefl@orfoocontonamallm f, wRacetonitril.tahngxinqui whe itoxicityycaff@rsrlarydiqsa).

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Themoun\ffeineceiduring0entiexperimpalXodas 9.2223 grams,rnver9aypproximately80gkilo,darC10c` mthdogo. 30>.tillwpt҃etite32 likewisenimgoodUvaeryighrotYdiehich9 alsoс_hlorifvalue׌׌׌B">Autopsy (32)i>—Stomaxpres؅sex flammucosa,specially fundusZpycors.ԁgastritismark /odxextendqlowholeurxsmtestine@ˇWnumerohexrhagarea`aicktalud wlar~aHduyab@parass, babxw艴l`ren gysePf spleen"hsid!engoI,@dney alganl DMFE">Di1.la@spaniei>?7?2FhaȊ(mvito[&ith Čusuin@doȥdmsthd0nɥw)no sigH!o rHwI9druggnubcutanePly,sympxIxicitydis,ow_[ed byu`‡Wincio 75ol!s@ʨafl`six8.ȧrog,ampsWG">N83:et.250s7773H逈pgepubid00109"itle="[Pg 82]FIaP_82ggdJ`/a 1߄Kdžp,ӆς???MFL? 2?9????FMxs:ДhcN 6, 7, 8, 9ol;'26c 2փxinjecʥO߄߄MFO 6:ּY0sexPYJhЫQtp@musc spP-14:÷gooX0.51ramMPi٤notethy.h[inuesomewhat7`Ѫhlg Q 15: 11YPm.߅765I(0.0( );a3deqypieemAuncomte; 4.15) ab`feump0up,CfbdeadRMFS">Autopsy (31):ungsged;tl0as0ؙ(@"-sfluiBQcardasac.̌Hreplyft frigadѳte ikidneys󳑃yflammfrtex; splp 1izscy;XacaP8eQmucosappyloPexhibѐ8e st@Q´xcrrh8exudates dž_thrºuodenummin<sPHmilGa;argYUy ItoُךU6x(r10Ѝ@5.39Q,rᡓ ahq53.9OMusuZlow9ancq(pЃ0 yronqasIexm0sses+psach) sugq؁Jibܒx˅e˒ SǏvityd ӆXlikeoauseiacɂc,ayY2XahssiHu8incre@ xi0ycase.

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Dog 28.aleoxerrieri>''O">Lowitrogdietbegunboutureek:eedingfaffein; 50 Zhnpd@reconsecutLPartialossappetite observafirstose."ximepressdesifoodteadh diminished,nkfeceIcamitid.ymptomintoxicationanifemselves earP#vomitccurrPth d&p`a3exclusXmeatXZa)Hmiss110J@9 mg=pinc"no,Dllow) areao 125Fis )fatwith620Ps7P">SstIsng,ightP.`)(r(hd0.269ram^ (88osn)Q">N@mb3:ׄj, 11.7t7773R7?89????8S?(?8;llrough@ؖhad@kepta@ld, pootilaaroom,:warmA0dڍ1gݕh???;T? 29?ww??Aus28:ӏXapartially慈ndigXm;ucosa show_;mxFIhamorrhagic倠ȋalong wholet;argق< sohib:miPσlxr engorged; spleenppearedormal;idneyslightlyongestinhrticalIon;therrgans wr.

Dog 24.hitendanale:asutnowrotehdietixeekseforexperiments withaffywebegun.hexitiXdosef 50gpkilodmX eɉsecutiveaysonsymptomsbservxduringxiHoHf΃ raCthintinutrefac1.etideces no؃halreadyfirstFinjecXioq)75re@,ild,xnoneabX vevXinc`smouOnD">One-ritrogؐ.҈ЌPai0.269ramOf(88 ori)7773Esppgepubid00111"itle="[Pg 84]HFaPage_84ggdG`/a 18Hctob02611.15pFood*dsrackmeL; xt, 3,ar2ǀtapioca, 10.Ԁ.ept a(ldampoompoor(ililovem0׈GGCI">3E14JP'؂????HK??85<;ha`o@rm,bedd)g gL 298O???8MxЈ:П@c@N B90UX25..,pT28cX1csubXaneously ide0ehoulders,ᣘ1halcoholey,Iroxim(סrQnoO 7:OOOO; Csoft:very`depresq pirieyduloP 45ol`,pl,tinflamYswolleno'???:Q?IڏhAmon0 ;gn 044@30̂p ; 4fʀ9 7773R7p2]54571l7777HS78@GbonoticyT 14?817(Oo)8.pss )8omfortablH?////(U/ 15(1qGGOHbyuthGabasoughckooooojVo 1f10sީ6(1 Z)oDŽDŽDŽI0 1R0eׁׁׁ1 18:gd *nno ߃߃߃2 1I2oxǃǃǃǰ߃߃߃߃߃3 22g0(PR 3 vomd—onںcapsuP9ft, Kbrokopen {regulariecohBO mostsiAr nwhintervalcoordindPurbqekbut exhibߌ4 2H9E{deatiffcolǂǂ5">TPtotalػ`ofaffeineceivedyog 24asetween 10.109nd 11.484rams. Asnefheapsulesomitp!intact!o(rrokopen,amount probablybout75ԁXfatal0seisȀhiundoub؁Hsan 185gkilo—somewHe25b.utopsyhowPheart diastole;osteriorob"rightungeep conge8d;rngorggallystill splQapphnormal;tomachekithemifluidassyloricrtiof exhibaPflamma\ucosa;Dduodenumeatly )Pmorrhagȅ(c(ludatremaind(sltialso/ild;dneysՊM,ese@rjec.

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