The_Toxicity_of_Caffein__An_expc*]c*]BOOKMOBI])81J7>FF N= VL^.fInvK~8K "$&(o*LJ,.e0؁2ܝ4688:<q>9@.B eDFH"J'L,2N1P7XR=MTDVHXLZT7\[8^b`ibq%dwuf{}h{jlnprt5vvxVz|Ƣ~Ԗ"hJ7 <F i'.26;AIWQDWp\cjoPty~m[ ix^4X וSL \l# *K29A.IPU W ^fjwnswe{g ;"$Y&B(=*\,.024Ƞ68: <>@TBDFH KJ L NPRTPVzXZ\ A MOBI N PEXTH$l3calibre (4.17.0) [http://calibre-ebook.com]dJ. B. RiegerdWilliam Salant enVThe Toxicity of Caffein: An experimental study on different species of animalsi(Caffeine -- Physiological effectm!Public domain in the USA.q,561eb39b-7d00-4880-852d-1a59297d8a5ap4calibre:561eb39b-7d00-4880-852d-1a59297d8a5a EBOKj!2014-07-22T04:00:00+00:00    kindle:embed:0001t m The Toxicity of Caffein: An experimental study on different species of animalsTherojectubergBookToxicityaffein,y..iegerndilliamalant8isbHforusanyone9whnUnitedtatesmostrartsQworldto!iwithrestrictionshatsoever.ouaypyt,iv (wPre-Iund؃hmLi8se clud:tonlith="https://www.g.org/l">.fa@notocds,Q’llatheckRlawcountrybeiingT.-24"justify{:ߕߕقSubRAnxperimaltudni peciimalsǃǃǃǃǃAuthorx>ReleaDP4uly 22, 2014EJ#46356]LanguagEnglishWWWWWPCreditHIducyryanesLGallo1 ODi!bdofr(Te8!pgdp.net ( asfrommsenerousmadvailAIqArch/AmcLibrarX.) brx)***TARTFHISROJECTUTENBERGBOOKR9r1">IssuApril 4, 1912X?ςςυ">U.S.EPMENAGRICULTURE,V BAUCHEMISTRY—BULLETINo. 148HDž"2">H=.ǁWǁ|ILEY߁">,ǁC@IEFQ">BhOOH3OO_X5">THEOXICITYAFFEIN:4">ANXPERI!AL@UDF__#ONI`RqSPECIESNIMALSgB?'??;LIAMALANTChiefharmacologlaboratory,visi@DrugXix,>DIEGER__^AssXhemXOO|ljljljljǦWashton..,vember@1.ǒOLjjustify">Sir:avehonoroubmitpyourpprovXanuscriptntoxicitycaffeiwhichsfirsxfseriesareportoedeyhalpwthd;conclusreľare,re@Xinomarticularregardative.ԂdatabtainrimariljuseIexecut܇oondjsct,ut*capableYmuHbroJl9wwwwsAcknowledgm ኪtacyn`xJohn.ohler,1PathV,ureaufnimalndustry,ndisssistants,nerformingheutopsiesecorded)treport.ɀmmepublicationɀmanuscriptxullet8No. 1485BumChemry.

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R337.elgianare.ׂ2, 1,040rams.iecarrot(March 31April 6,1lusivei><: 3pzheack (0.2kilo)ѓǑmu@exaggera_7: 8.15;ώZymptoXgg6gggggggggggggggaxtissu0X͉gggg Pwplthoughpped3Group (seabl(page 25)oPsami(aftHadministLաH'zprecederiallmxrYaty 2¼ours24d.wo| (No19nd 208)ereH\orvPlay]C,ҩswoatPSdeatht=ooOresti0zmayP9dthaPlesxichenXnӆY`exLHetsNo.ypoornishyulc܆;ctumob vsQ quit`ossiPmR nؓ~PTYt(Iڥzqwhimofrfrom`ityҐwehEgsurvmanifmil@onX Qou9adB(creasQ҅Isu 9,w1xctcaugȝ0paoG~H0lyacx''24748WORhek誀C!Gdisregar'''0f>iprobabiduɦ"XodiHre`*aindsupport@nnexȮAer">SERIES Cƒ'''75ob!7?do SmPRoҷgr)obt؉lvidjva0tɍ"*.Ś…xa8B252g9ilogI thaumbab250,2,;38lAw (SrO)??/oweekdingT⃬8@ x0ibڙ•0o????; R122.׈,@`WB@,060!mD,#April 14: 25cf 2erentaffein (250gkilo)nqueousolutionjectedubcutanlyatheackt 1.35..; 4.30c,remors,eflexescreased,ondi2o`rwiseood.

Autopsy
:ivdeephgesP;pdneysortexႰmedulla;tomachhowmallrhagicY,foratinglcer9ylor(pЈ(xintinetechia(mucoslungsJspleenorЉxRabbit 234.hitee`hW:, 1,6@grams.ieNovemb2-90arrotsi>V9: 10.4520ɕ242admini8r7410a,g'&335.ray萰GG17GBMar31o7wwwwE7؝\14__X&WT;30זhȈisxAesensveW8dߟߟwa/dptaealccidios@noesdndxwithAryoHashÇ(hi`milPatPhinflamm)tNhlsoht2ew''''w249.elgian85oaσσσσϚǚ1:r, كromladdaPilitmunugarRalbuP1.36OOy; 3韄gohyHæssiarkbutteXnh(hxlqPuhll˹4ducCfehl@''siabߋߋߋߋߋ2!8Weavynawubh!imȶ obd/e`d(noPc;genfEяympَmXoxi'21.ellow13">169Y4GGGG;QǕǕå@ϛsȂHrutp@pfloos@cept0requiforhmovreturogcXsoftO[ą߅ganordo0z0walk,Br2/VappettseemsQbeTz25ф|llZ)????ױ504Qlhtwoays`exhn)G_ä''ճ"g1i,(252Oj;_6o,,o8ײh hmbp:pHbPk/?<834???9270?9rot`31April 79pÀt"idth="0p`align="justify">April 7: 9.30.., 15c 2erentaffein (240gkilo)njectedubcutaneouslyheack; 10eflexesuch@creasedabbitxtreme sensitive.

Rc233.hite,aleh*,675raiecarrots,ovemb2o''''%&9:52038bserv(unt5Cwhenandy(æssiaeretic9but teuχχχχ10aralysifosteriordes;i@at 1σσσϒnresult tainؗexim؁\inspQTable, page 25,howxallour^rsisurvdos 236Q252 eBelgiana.ςJӊone wa.ԁorreeÁt. wos fat 0receRuringxvdays!dadministra Tь@tx8embactor,9`ortoxicityxMP8may)^*|No. 122},fpdI2hGoґ(sameߐPǘ////.E4z3@orpill,jGGIQdependqupQufq??caurpr@dtalq.t eviِߐ؆dieQșaqP=ɩah8babil duracZכ)P1m@`PpvaI.ҒW335:sEncepъ憎-texa ۆɓ<@xoccidioo씀AQlajrgva@d(s l0Ζ'ler">SDƒ'''ǙTBhˉregar./ؐŽRxascerJsayureXgr($Г bjضx`caqygّ@u1*A35ŰОeek҉inٰHԔ@dngyrom 267!30yrϘQotaduls 253.r!black,lW, 1,6xmxDjN8mb 9Y12Higooon.12: 11.30..,ddP, 0bubsu;522c 2ٖ(275lo)dxsubcuPeHly4jumpe3ablhhvulsreheophotono(generrexؗȓexЏxetchYuة/-almpr,equtwis;10tI15oooom252ȑ{feI''''!18.Փ󝭓bz,l($2gre8iAnoticbon; 4Bnd,]unusu tsn @lljbynth;ckƆAbadÀ.ied 4.35..

Rabbit 327.hite,emalex:, 820ramsoats,arch 8o 16i>16: 11.45!, 12c 2erentaffein (292gkilo)nject subcutaneouslyheack;Qfoundead,utastillPrm. xAutopsyq:emorrhagicreatoiofionPspinaluscles;bdomregexhiaargecheesyurulmaterial;ivaspleenerengod;laddfenesor40 brownؑ7,465GEσσσσϐ30: 3.P ߐ273ߐߐߐߐo1: 9Mwwww߁_^1_\705w777772704.4Ɗkdyingondi,adyvuls,׆׆׆׊w6ƖS60Wǧǧǃρ(91noQ4קrYsrkehyPsensvstariruhpXfloor;򉃩notnd0yo@trequirforimovfromretur8oge7H.30epretzorwiseener&oono+ymptoȄ8appet2OOpdabohtom235.elgi`h8 carroNovemb29τ____X&1.025חח67חחחԕeflexxincpsXteobservQGexorn WWЋWRfega86W7777'C0DXGGGGGG.1^somewhatOr8so;lhga0clumsy*slow;ofxp2.3G#lBp)Q,steriȏ8`Hx`endtrigixanON0ra;ubpth;ccayspasm.҅ ۑh Autopsy:e!)poipȌapiImusc;쮨rpleengorgbȅhn: hansYnt norGGG9741Eo____"gX17'$87''''; 4 .; 5AsamФ____\9,𛰞:ҧ21,2`LGn 2757lf헏?????;3ޙL2gXsafairwediП.muc@hryaflammatory;Y ts8loquidInatuAql{e(ZBance׉׉tÀ"lign="justify">Rabbit 396.elgianare,emale.eight, 1,475rams.ieoats.

gfriablgYcywePfillѐgastr𞨆KLmesАh!գ mark)c@/wwwvTresulۉexPimuthiIlikewisdtemo@ЦahCr*va0tH.Pus(Xry(No(235, 316(9P396),hireced7 28ʂ],woid,[B]SERIES E蜔'''ItaÀshownnerieshat 0.15affeperilousedymptomsftoxication.eforeoncluding,owever,thiss@emallestosehichoisonbaumbpeximentsexmwithrs.tasound[Ȅ1grehmajorityca mayiuresis,utoervouruscular>omeabbit0uaKprov(fatal.ost-mortemaminZ({ApenceboccidioPylia@iillecsimi obv2made9quitossibleIH ''!ampantctdecszRt1.Ő 551 (p. 25)Zoaydi# likewiin2 :

R 325.h,e`xWB, 1,065aDieoatsxi>Mar17: 11.., 6c 2c(112g>)injectubcuelyback.boxcurinqueezȀfromladdԎ o׆׆׆׆׆hilegsrx1stretchkpro2alsotended;yonȅllyWWWWWV5.40mt vPVrw:m8: 9ͦdead,ffcold.Autopsy9:erhagic8tYخoQ;reg b讁ghsIainfiltrJtissues;,tas";,orgaapppnt(npljljljljŝ'330lgi8h_]93L;ors3.ؑ\❏(107ϝɝ׌ъĝck;3(DžDžDžDžDž9o|25:N82gggg9w)77wwseced͍$wwwwO 4 3DžDžDžDžǏ gooD;gggg lȏ׻л 15xapwrobt;|y(stp8rPawayhenظnl;8itourwiaixpa;iЅ`bserH,Ѓbecamehha@wasnabloplؽʽ;ft runnهPbainuteyspnœamarkKoraishimselfisYupgבWWWW׾iPll@rmLunstuLs8ly0Hipnodu,dhcostaleurarobyohs-.ȐrhagatȂiinocula)ljGGGǟ51.LJ知Janua`2665;d 20񄠤alcoholai0r-31߅υυυυȂ311,4ݝx0.ptemxatu101.6°45rU7HsubcutaneÀouslyntoack; 11.15..,onvulsionsfhorturat;aisedimselfnosterioregs,nsidepart; 4.10;look@normal,@typersensitivey3~dxseemȅeood.

February 1: 9foundead,asvt 56ypreviay. Autopsy:eÂkinvolva acicavityainly;unerepzhaaibrolacxudateuthem adhPc aleHȅrngorgppearhfattno8rlaffectingigett httarrhtomach0`HiceableeaturHkidney@s enčߍߍߍce">TABLE 10>—Subcutane1injdcin@rabbitsi>"br@)tڃǃX"rhlspa7w녗SERIESbNoge׋߁߁߁߁b>CK0kilo>Aanchympggggg>DQlife''''pDiegρρρρReIa}d/tdGGAi>Gram-ρρρ mMgooo瀷W߁g߅'332灇1,070581our 45inutesSurvd Oat/(y}ߋߋ߀?33171߁3d{D'''/'2%20'%7'''/%65'ǁ}WhitWWGB2177ǁT35W47/___///X97\82/_7/~MalߊWw947ׁ4977/OonÀt> 191LightrownNJholspa7"ׂSERIES,ROUPɃb؃=h?W߀ߊ9G'4782102ours 50inutes31OatWhitegg//G.6/,58,0/1:About 18ׁׁׁכ7>GrayϋϋρoooP12787ǁŁ|BlackgggGg97ǁ4068߁7/>Yellowϊӓ3_߁7ǬǗCarro߁ߋG0ǁ24ׁׁׁׁזyholspa7"SERIES,ROUPI bEhG_4772.5/SurvivedOa׎׎׋?oׁ}DGGG/633׃4ǁD111ׁ߁GGwwww/g3367vwρdoÀ.dozDz/trrtholspa7"SERIESÂbh 12272,06052ours 55inutes1.5ayOatWhite׎׋瀏G347ǁc,6g474AboutX˂ׁׁׁCarroׁ׀/335717ׁՁÉꁗg}Grayccidiosis978?6>Survived㋇?.217߭10߁{YellowO׃ρ4?3Ggg?g_2ׁ灟__///)37\6786>2_>Whiteߋߋhlspa7"SERIESĂbhπφ0O$?/">Brownndlack3ρS 5G߁BGGG277gÀn="top"> 820 34_ǁ1,4657373About 18#ׁׁ׊ρndrown175741 27Dϊϊπ/26764灗4灇50ogGw23ǁ876774W>CarrotGray?6176o' 4G3 >Oa?/ 9/18?/SurvivedW//721">About 2ayGǁǁǖwww///rv2wOOOO/?OO24O1Z18'ׁׁׁ׋/39o7Wwwww/t87t57u_745.5_top">do.<Dz/trr///> 39971,72500736oursOholspa7"SERIESłbho\߆n06122Lesshan 2>atWhiteemale3w93 07NoneSurvivedWSGray?773_//Yggg灇&4%'74ׁBlackooo551745M30inute4'wy߁nj/table>R248.elgiharW:,70.Ī,iidth="0pƀt"lign="justify">November 17: 1.20.., 19.5c 2centaffein (330gkilo)dministeredyheouth; 4.hsomewhatysensitive.

R241.hitXale`",380rams.ieoatsXi>W15]H29ύness,utor^φWWWWV8:'''''' DŽDŽDŽǎ 249.elgianar' 8(ǐ14' 25''#9 wws10}׃0ώτIer">SERIES Bƒ'''?=TXobjasexim8sasoeePmumatalo)twoaries{xwandrHy.ll,iepproxtely]saw__23_Z,935߰4v7ggb63ggb,Howp0.9sal(:th.)Autopsy:̊h tyPgrashflamphsha`i p;Torgansr777687(10///OOOO/*2BǓǭyt.1shwh8hysenv4.3ffair0Ӭu ,L2Lbloodyooking\obtar8bladderconalbu0asi@abl88glyco(;Mdieo?419,,6Sept602ǐǏ̈0$<; 6EXllwӻDن7odungl @kidneysgedpt"lign=ˀ"justify">Rabbit 420.elgianare,ale.eight, 1,250rams.ieoats.

TABLE 20>—Adystr~mbyouthi>br@)taAwqtop"rh0lspa7wGASERIESbR肟׋߁߁߁߁b>C|U>SymptomDulife'''''DXρρρρρRώ77GraA-ρρρ mMgooo瀷W߁g߅'248灇1,170333oursSurvdOat'y?w24173892dف~Wh)狇o97825wǖooo߻߻߀ǻ߻BWX3_ׁ93߁\637gggg߂ggg547灇774About 2ayWǁǁǘofeߊߊ߁www677d054250inute/1G87ǁ10'>ˀfontize="2">About 3ours 41971,600356ρLesshanw>Grayaleg2灇2/212?__/^17\485\ρwwww/u479w293?wo}Whitewooo0w'WW///Rn4ׁo7½灯'WU/table>INJECTIONNTOHEERITONEALAVITY`bp߂߂߂justify">InumberfxperimsaffeinasntroducedYoePtonealXvity.abbi؂PdirHrietieseceivingdAoarrroXwmployhfthisurpose;odnd{give@dium.ԅminimumquirinYymptomuseeathxaaldeed;esYih6!ho`denouPrordstudy"influenhXag€resistaɋrsubulashownllow)os:ǐ9aǐǐŁSחҔES A꘯'''fSlardsed,pproxta0.3ramilу  71.rayeׂ*,(659Bsi'''&January 20: 2.20.., 25cqueouolutiP2r!>(g>)inject; 3.45whdoorjcقJope蛠spasm)0rturon1:DXuHdwwwwo2lhit02777 11.17ፌ0.2()QǍǍǍč|romurett(paraly30ōonvuls1Zpick`upâJl,ollow΀edyeveralpasmsater; 11.35..,ypictetanus2.30oon,oundead.

Rabbit 61.lackemale.ׂ*, 2,143ramsi>''''%Jary 19: 40c 2erentaffei(aqueousolution (300gZkilo),njectintoitonecavityromurette;ehenbout weref;removЂholder,pehdviolonvulsserminating!th/er">SERIES Bƒ'''/-Thebfhesexm8(asoeinimumeth0dos0.2Q0.154fzwqrZsi`eggggc 69@hite1,714///20: 1j\6.oymptom`(obvfor 459ute(fecrxAopily;8cepsoft9υυυυυυυty,ȅυυυɝ˦b405restleseflexincrease/____70.raywǒǒ487ǒǃoooǒ 0錷G ()/~ON2.2'7777530AڅЂ&iO>Febr[:!Autopsy1:irrhosi;)its`l (sachkidneysr@?>93.al0e,19////Marp212g2GWW7আ8leXghl?9MoccurredttackspPclonicnXithrigidAHpos@ext dur9ղHwe@Hla/*PaxLJhtweG` sthoXobchicregb(kyp#lumbar ب| { pupilԮߑǑǑǑǔ2.ىow388///2h44OO4/Nh`(>։foPretch cag8raihimselfnXeggainٳAgenerwhaouω6: 9dead.HrhKabdomusc;ЁƗ`owtopsimrpob/oooo76309.elgia0arwu5Дsieoat׃σσσϩ2.0nϔϔϔϔϹߟr9e@bladGGG07zHσσσϳ2xon,obtȰIeamb olo8albubu16n0o151όόό϶a7plac!nloorupari梱WspendK@Ґa',aHys,yspӀnœa; 4.50..,bout 100crineollected,olbumin,eductionfehling'solumoderate.

March 3: 9.30posteriorxtremitiesaendedndigi anONparalyz!respiȅ!lessrequent*deeperhanprmal.abbitiI1;ince.reviousayaveerypavy'''on. Autopsy:ninoodndon;thefHxilla0regasbservImorrhagetosubcutanemuscu`issueAt.ԁv reZar؈ophtactth abdoPwall,howicreaone-halfHlengthu(mQeo`byxpunctur(rruis|,Prougㄧ.ȇ'̀eHadjacaˋaffa8mimanner4rorganseXap؂ly}} 308.elgih,ee.ׂr, 1,3grams.ieoatsi σσσϞGh 2:45Mobta@domladhe`;!12Prc(0.15kilo)jՌit@cavityAnot Pivbymptom0rw; 3Clookxdessmadlittltte`9moʤm` (stimehenlhdP惠rQo18''!'''kstȘbPPkeasif@gu :Mdr_[hsid釨R sPќ9p;noe#did2eoooooi4I]lyw X70limp//)d2.υυυυυ50fou*adLnged;pleЃgّen kidneyso\Ѵrtex@a@fjucosaXickeipu!f;PtechiWner دQer">SERIES Cƒ'''ߋݽexit`0}dHrhhHimumxdosٴ29520carro 1p0.46 2hefo+[;hזdyXe8nc>u*(3鷮ގg?;well2936熇Ubladllkn11.5583u;# l0/OOOOψψψψϳ3.15ggςςςϏww92wsgc59ggg׃׃׃׆\1^GGGGAwreflexincr`w﫨rJ5NerH1 {*aleӀrineollected;olbumen,areduction; 3.40..symptoms.

March 4: 2urabbitooksell,DŽ,idtntainugarRk298.elgianare,emale.ׂr, 1,205ra(iecarroti>LJ1: 4.067.5cYerenaffe olu (0.12C2kilo)njҀHtoitonealvityobq8fromladdimmediatelyftzx5.3reflexescreas!DwasbleunrounbutecamearalyzsoӒ4i(gQ_]ߋߋߋߋ3: 103aniorxtremiti`,usosGGGGG1oߋpr2316׃׃׃׆3.5ϓϓclearmbiolo𓗓ڣ5??;(mgטטטtyo0klittattewhen`theh weaknessf(marke____.15ǂer">SERIES Dƒ'''TobAex`tthPsؠɊstudyc ag@resistancD.alf-grownYhPؤ8;owing2 310ﱗ, 880oa׃ǃǃǃǐ 2ї|9''!0.27774O/9yomsߧߗ77771%Wa1iwallac`Ϟmade?chanieasidso0t{ Xon'''''"5Pf)ead.Autopsy9:iv show0(degeneraCkidneys0apetechi hemorrhcortex;lRlarؒЁ(xnflamm ;dend 75.raywhit4;ggggaJanuary 2X38ϛsolur 37blexincy7׆׆׆׆7:Ҋ{paralyzbДabЅ`turn!/*back׃׃׃׎469gggg 7#OrecAhoɺoom12lx74p.47uurbtfromՙppenc*albubЎ@Fehling'l;i57?OOM2Jǁsigi "; (")Vdiϋ>ӀRabbit 311.elgianare,emale.eight, 650rams.ieoats.

March 3: 26..,rinebta@dromladderorhnppearancalbumenonsi8ablreductionfehling'solunone;76c 2Pcentaffeh(0.2"kilo)hjectPintoitЅ0cavity; 2.309seembe,@ymptomsdeveloped;coll[PaargemouXsugarnaseryavy,utafd h 4digood,ovesbowhppHfloor;ai 78.ellowndHit9'////">Janua268O 8.5ooh(2mgthobservathesaafternoon?8wwwwu7: 4]s߂߂߂ߌw'17''' 635e(h 150.48ߌߌٝ512 markbilegs,RunwalkÝ)ittexerɠNdibetwe1RP( Autopsy.Ҋlung@pxzshowYdhes s)costPianpleura;tuithPdulcoccidiosis;󁠫#gsafiaupat;qH(s;hemorrhagiciɍvprreg28roX;;dneysߑǑǑǑǕol237482O77wwww714610??efl0creasɕԓ8ig,7il1.4trAeakPwqeȀzhqthat}NJWWWWS`COHOOOOOK8Orec app@ntlym𲠃????=S0extSh(AhhiPwe(PsrelimhPAhhave*([Yܑkrxc̈́IArapidHabsorbfahldosЅeoyuquAtrialydrug.h#B%mayXvi)wo oup(GA,!g٪Ss 69, 70, 92 330epdLPNo307l8,0.1;WWjre\$ ()from˂c$;pypnu8N\qhourЀqA-halx٘spvely"adPr0.noPs/pp𳼉fG&fmad󏩅wPnotiurvQsammousropoʨibody`"(Ig(Amembe 2JXQii|accfogH1IQ~`.eP߀70YeQexcep"Ȉt)tsIaX񙷌'.ͱpacroscopicpexaqʧutopsfGDilozys3k)s ϯϯϯϯT aAep)lAbabilamum;kd<;//-s@ultsfӀhexperimentsnhes,iwhichmalleroses, 0.125ramfaffeX(ilousedildymptomsnly,ylerarelyducany.tayeemarkthat(abbi@ere0carro胳]No3070d@8ceivoatTheirsistance􆙇#Ddixr,u(a pointAutearli0part)thi)vestigation,pet؅not8eminflue@toxicity#eing'n.č150 Y00mgien8jecoڐitonealv,considd,pȉminimumatorry.naly showsugreatp__ajo(@ iitraly1uPaf adYs@10.272ea؀f؃,儰ct:obp҄w(10,(1)e$-74, 75)de8opurv.ϛ؜,I2droPq;utops0pdegeneׁlrpetechihemorrhagcortexkidneyȀمȍӛZrobabCKatЀ(

Tdeci)cȝYeeZ,lѠ8urBhobulYbtain[i@larg.҃ 78=257ϟfaЎ8owrammounJhp@body )23Q{pid<v @lllfxtu1usdxdi)evえdiseY h<׫/willifJبCembyUy8gfnЈH,\aaljCɂy8kewOBad].i@aړBғnvAnrep?9tІЋخꀈfull-gr͜O¢ʅ,0oHdxdiuretrfollowtxydic𷃅0muhnHsI8q`saAràPer`so`؍,moPDsug;!0.15cgPn;bu?EOi>mbp:pbk/>C72'''''b>Uρρρρb>T8ǁǁǁǁLJDρ/trd/td//)i>G@Q-ρρρ mmcco߁g307灇1,3201$04.5OwG87ǁ058Ӏ0o.Dz/trr///> 29571,20.10Gours 20inutesCarrotsoooo_o37߁l6oo9{3cG߁///275ׁ߈gE4灧(able>OTE~ׁ—ThemouofrineecretednhreeTbyrolabbits,nbiet,ribetween 35nd 50c,xxverage:nimal(einglittlbove0rams.ԁpiQxaCasuchessorequaleriodime_p="9聇center">TABLE 3PIatoneHinjec19ibY)z72hlspa6w'SERIESbho􀏂>Nɂgb׋"߁߁߁߁b>Caffilo>T aappearancrsymptoms >Duralif!''''Remarkف_WGDi>GρρϨ?=71?߁590.3  85inute2_qyGGG?=6G,143C?W__te&ςBlackG2/40">1.25dhitWB,ROUPɃ0/877m0ay__߉__T9^9߁2灯ρ.ہMaltese;ivenecondosefter 3ays,ied 2.5oursa. 1,492.2  About 5inu߁߁߁߁SurvXdWhiteooooGe߃n388oo?24KYellowGGGGO=30ρM500OO_T0g">Belgian;atscolspa6"ERIES,ROUPI_50.153|a4O^ɫAׁׁׁ׎׋7721 x/!Doggg{C_2237o165-2+''warrowwwg29wu60灗??__XdǁG72__77729275__77729烷7Ļǁ7ggײcD_~1o88U22ays .2   3127740//40inutes.5ourMal8e;ats8/z659|5715_YellowndhitGϊ5/Gz84dGray_ߊ///ǂ/9///WW7\3灏 2WAbout 2ρρρρBelgian7׊237;2OϊɨWNJ/table>INTRAMUSCULARNJECTIONbwwwwjustifyH`-fedabbits,AcheceietxcluslyfʁXeres0forhHperimps.henjectionsmadHumbarrglaluscle9_>SߋERIES lA/'''InXis`esas R 284.rown,ee.ׂ, 1,100ramiiDmbe4:p..1cyȋ (0.2kilo),ndhob@va)til 5harequjonvulsa;t58comato0dia.҉fo`enextorningog286tebblackgg3،gge5`.30~31977treszincreareflex[dur؊gtwo,@norymptoʇ7:M veWWWWg5, owo38gh154gener(րRabbit 287.elgianare,emale.eight, 1,140rams.

December 15: 2.15..1cf 2centaffeinnjectedHtohelutealuscles;X30]tonicontractionsposteriorimbs.aralysisndeath(.RYer">SERIES Bƒ'''In0esˆJwas?>lumbar5ooon 30ߐߐߐ75߆߃wwwvFebruary 16:x.05ᎋ8ِǐLJ(0.1362kilo)??kund(obPva til 4noymptompallowpwalknfloor;f0inghortistanc os:chdinp>/(extremitX; 5.2foyd306y86Wooooze12.5ύ12on Xabout 10eHexha; 3ˊ7777181_1,2_ (Wxeximdasomereviously.) .57 www/\,ؙoretRedИ|zedO'?'%C'''''!asayeaddonserirؑhHwixdosrangfrom0 28milГʏ| hichӐ'''Ԁresulhive[o٧bbaaprotocols:Ϛ425hX,5////-Septembx27Z\7'ooOOnreflexincreasew28:҈norPggggfOctoQ5:,6.5&0߇3r 13y(131g׆6ƥw1φWmux|4:lי2ooo@ggoooOO`7WW ޙg'ggggggg_gfN9ooo_O__ __\42_____φWWWWWWW6,oook7ooo78ϙoooooWigooWl.October 5:ׁ, 1,850rams; 3..1.5c 2xcentaffeinnjectedHtoumbaruscle.10-reflexesPcreased.l453.elgianarmale._,16\8i>____ 2:45_queousolutiooo; 4.1΋paralyzg____߁ߔ 9foundead. 8Autopsy:astriccosaHmorrhagic;쏨rarkenothorgans`r?55?;yxe|85xwhe盏w1,07\omffpoisoninggBߨwwwwwՂGumphoffbtablhadttackonvuls8siFindțame!o.////ϒ28ϒϣ76n14.8//i0.18z׋׋׋Ј76蟷7777gg9gg71,3P7____763ϊ752/// 8^ooooer">SERIES Dƒ'''Fureximsk̜"b/rʀygeal,re(dethiw><577.ǜ@ 8February`_逹rde;د~st8(??walkabou45pas ar,traw-colorurin04(low؆ qf(across#oom` 20e looti؃RetcQhimselfhoe`pXni95Gshow disturbanceqgaitώ9՜_O7Iegug////d.0Дnoϔϔϔϔϔ5,⌐notv; ߑߑ,symptomPbxvGGGGGo57Whit۾G1,49oooo/p(cagȢގOUntak0f∂ol뎹peciicOOOOO23:tillveOight="9ptۀ"idth="0pt"lign="justify">Rabbit 580.rayale.eight, 1,510rams.

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Gram)i/ρρρ mmg߁g7284灇1,1000.200 3oursLesshan 20lutealWhitendrown8leGό67O315.1977SurvivedBdo/+lack//G/ό,O.-ׁresentYellow"wr'''Oׂׂ׌#/W4%1'15inxo2gynjcolspa7"מoERIES‚_07߁13'56,>umbarGGwwwB'E86E34׌?4D781723>WG@CG_2wwE52g$urvived?g?o40?423g'Njwg&5350inutes 45371,160.203Lesshan 20ourGrayaleg57灇8">Survived'fewww28765'18?ǖǖǂ///ǁ߂ggg97灇34ǁ?/7W1colspa7"ERIESĂ7_5777o5ǁ0?1WP18WlalwwGGGggg@灇7u1GGOOO7757M49ǁ5">Whitendg/75߁?Lumbar'NJNJNJǂggg17灇%Wǁߖ߁5w777278ρ194/table>ExaationfԂ 4howshat 14abbitsecerom 180o 2ۀ10gaffeinerilo.heppearancefymptomsnheseabbitsariedonsidely.nomepcreasreflexesHuldeoticЂ@to 15inut(afthHjection1T;ortaselayh2r 3ours8tghtyaddthat…xet׆occurrmanypsXveryhadHistraՀdrug—QagXbout 3xdSed.smalleroqwer`Py'P8lumbarusclelA*Bdulif|14EBSm with20;ixurvivZ0.2ram_\Hyregarhamumatx,hiletoxicsbwetweeЍandșB

INTRAVENOUSNJECTION@bgggdjustify">0xexhimcarqwell-fed,uPgrowny-|i fdaysreingj_᎘@faots ch{g d(pum{Fmadhifromurettpr)mea؃artemathM5solurbpg\40°ÒЂnalsoxІ񄕂8cЄaf7⃝onit񓷓)Ale3deȁshSpllowys39ђ7SERIES Aƒ'''WU ۅOOMKc2rwuѪCDŽ R 194.hit@fe`exB, 1,3i߃???>Octob019:X 7.5׆(1!W).҆fnesply extremitiiҁi>.wr[C]/AޭljljljljŌ556.ǥ635///.Janua31:i..ʌ猟134, $1=; 2.H$ vuls,DmaBly0;i-resFA0cHPy; 3.ρ6FdidothɐJЈwww5758////.Ȁ@7 7^at_ǎf)liquhceasѶcengorgqbleelP'!HtOOOwoHsk5ƕ%aielftoverAassumnor8Xtitud8walk2jlowittanifHbny0g gz; 4Yuga@dH seeɐbeooWWWWFebrZn,r,xt9mou, 9ς,(1589////: 3g(n 8ogiolr7osXtchВ98h abdomeWsaend|7,oo1;a /.292.elgiaH,ȏ_Y770ramsހ.

February 18: 4.26o@39.., 12.5carmaffeinolution (0.141ramerilo)njectedHpear,onvulsfollowwhenhisuantityXs,nicigidofimbssoafter;52Ճpiunchangqrabbitloor,lstretchpout,ndyingIabdomenߊߊߊߊRs294.elgianare,emale.ׂr8,350Bs.arrotiet8r 10ayseeexit9:I20叚Pc(74g___Afiveinutes,d酺aoPrus3Cnrepea/s; 1.25܆llYv9requ attacks2.3foudead.ota0mt58Xr @G葏~Itbebservprecedsaymptomseve،axicaws9xaDsixhbonlywo se (No556)domcc`ɑ+.ρowhichurvpahreeXce 011*an˄Ȅ2)QW_ԅXthΆayregardQsaexcep`yowsistancoNer">SERIES Bƒ'''/-D 16j2oemploy>؊ry#`1Yac,إ䁩Ev 254,910.8 rodu7Rses 562.rge6gD(a 1:ɊbPt 32;01Sp3 灳Dɻ\byiolzW,rkp(hoo4߬;h~G16G61411.40h8trugglY7ʈk50B끿'55cIHopp um GsXstʎ4solua1W/, dotrin8,т`yeLbladderggg60ןl2בב׃wwwwבב11.@GG1dgRnextDu!Irn?? M 1z>φˮօis0՗<aflexhincre2xoneicזoffЃil CpnmadQetchPpabdo8,miti`endedGGGGE2: 9Uς7759GB875GGG>Jan3@G0ft?of@ W4.08ڂ?7@n2morlyAoj_*(19gkilo)ebrua ry 1: 2..,onditionood,alkedbout,ppetitepass155cark,eddish-brownrineince 5.30;reviousy.

Rabbit 279.rayndhfemale.ׂz, 1,320ramsPi>wwwwuFebrua024: 10.09[6erentaffeinrapidlyntougular;915=involunt!twitchingfusclesYlegs,utothsymptomsr23oJ6, 3߄injected78,hovuls؃9to32灃1}rly2tidenteriorxtrem0paralyz pos8traclonicnreadee imorlowthanrȅQ.10ojdihadmmediate0befda;mo9WUhois,r 66 kilo54.elgi har@285ieoatwσσσσNovemb12p1/b3`.47¾receiv0.8(from@retXef< 6.dyspnœa.7strugglGBat50½leayholderɗsisspeciyH0hwoAcp,urv;tal 17inutx25ndǑǕ5ǕÕ102.31؀P5¼3"; 7'''/'">6'')46/>5WW.osolbynou];8. wЃMan _;)7et ww.?8(158gF)*5/(3.776567.rayWW߂߂߂߂February 6:ɍbeg04.B;a8Əʡ21h4resuYroducY8ŃwȐށƧϧ!b162lo4z[posב5fdead?ggg?Iˁzp imsmprisr†dso8,4(79H"5,ichy saasoupIos؎(60)6{itly.p56p5q550bou00?SERIES C<9.

Inhesexperimentsinimumoxicowasetered.ԁ8conditionseresamesׂofo(resЅ Rabbit 293.elgianare,emale.ׂz, 1,610rams.ieoatio׃׃׃February 18: 3.40A3.., 4c 2crmaffe`soluQjectedHear,avulskhen 3y,epeaattacks;raistselfnegs,utllvimmedilyndaytretchabdoh9: 9ᄥJlooknor,pphnt rec?227hitP2,32폏">Octob2629¼37½wufrom6.7,pymptom07isXtinued;urviv 568GrP5o hIibegat 1.0(3.5p(42gkilo)qfourute0.6mowith|nextwoone-haptotalmouhF4.1`;(h,hysensvsturbanc0usculcoordina;stlessn 35..eflexeQcrea,rўwalYaboupga.ndxobvR9dayhs`ǎGGGǑ64ǑǑ515ϑg'''gggg1.266|Yr1:3>inmarsi(remВ,?ت_PIqu0x8e abloop1od?8icBfot׍׍א64WWSSt8[IBfcea 20ravenousXr 3aX:noo7Qooo66ooj90hggg3.05WT3GGGGthreW31WQO>Thesshowao Єohewromilׯuchd~.RsbС`4hcQe؈]!eaxc@τ) islquant$opg_[manifhӅH^swsmayha bxHrh`imumxxics''͛Scondonؑ????="er">SERIES Dƒ'''_]A 00ϏsoluruǎoohosʑonʉJity;X{gR׆ 5694711.(a 12.0110 ׋׽31߁߉126///otX́cc20,s3"Xurine3grefle xes,utoonvulsions; 4..,efle8ncreased.

February 11:live,idit`ooRabbit 574.rayemale.ׂ*, 1,555rams.ieoats`i>8: 10.25oI33Cinjectedccf 0.5erentaffein0altoluňIdistinu0forP퀀teq81.10 30,talmou]Pced, 3!1.vesensve;markedlyw91ؐ7:ɍ3.13.50332-,8tyW5stlessn ndeakj`extremI4urol!anteriompairctHparetictri` walkbou8dhe`mefnoon777684'#60'''wwww''!5301wX0gg03sumwó val14?otravenousA63292.Вurina:blxyʕ؁hg deathwFlpr.utopshowgv@eraoPreҔ'''70W7227777: 2.06ي624ύύʻ?>,Zsisspecial@yupasَzhichHs8r!appearanc1DŽr7ƕhd. da:̕`r,plee09kidneys-largehemorrhagiomPum:\peis@lse0duHAadhYdiaphragm;E|AabdofsOfflths(three8ald raEd.Ԁ+3surv$mil`ymptomnly0uHX_evid^eoisoningob0䄘߆rdos`) Ae 2N=.Ûicoᇊ (No.Q);Ɯ1!s8571)nВHgroupPefor@2m鋱raG@ aXr,p)gs1DHI׉Osouim.ɡsuitqobable1tCXrhxtuoudav0D""1dimY⧡mportactJт1toxicityXˇiviffKe1!mxcau8alyalpXoxorga"er">SERIES Eƒ''' Isqex؏n''zpossiflu".𝿁!CM19T-halГu@ψR572.rxe.ׂ", 1,7gramDieoatYi'758:ɊbedЏ k3.37 resumedt  3.38..;abbitasestless;njectioninishedt52otaluantityceived, 17.4c Herentaffeintravenouslyp pminutestrugglH8ermitt@duringhe;)ioregsaralyzed.

February 9:oundea?????RC573.rayale.ׂ,810rams.ieoatsPi>wwww8:tarttoI1.35hisconu2.27΍ 18flexes@rked creassoaf;45,sbloodye; 4.30v.;orymptoȉOOOOO9Q,?I@illebserthsome `daofonsetiBcaujylow,utқul뀩sa8`whenɀere`deorapi.tsiterobable,!ЁHY@auchrahwmside؄atoxiciromjsEeximsϑsum`i8a3appear10ٖ@imuhosxsasoluKÚl1iSHsbo50gkilo wic inducsevYAfa; 16WPyureHp%hdiᮡǍǁ9;)ePnotnQws8suppsPzexznXa?pyr,@epȢer">TABLE 50>—IwSERIESb*Noge߁߁߁߁b>Cܖ>SDuTlife'''''ρρρρρReύGra -ρρρ mMgooo瀷W߁g߅'194灇,3101PpSurvivedOatsWhif8lفϋǁǀ55676353ǁ1ؼʈ2d遇"www7758D7587}90G>o.ā/trr777> 29271,77041GGGGG77947D35G26G">10inutesCarrotholspa7"SERIES,ROUPɃb؃=h?Wǀ߅k566ǁ07½ourWOaׁGrayemaleߊ߀wߡσ4߁߁7O7ww777rgN2wPresentLesshan 24ρρϋϋπ7597875ρGSurvived'gggG_wY7vo6w7*GGndhiteNJG?GNJC547GD28灗Eǁ7W'NJׁ׀w}7772773About 45inute瀷w''''7g7&58773DiߩgggbCW937ׁ61W0Presentρ>< fontize="2">Oats 2277,32057NonedoG74White튯ooo 56371,65/0PresentǁGw64751546G771D7www7w6烷v47wGGG777A67D9ρE1GGGGFholspa7"SERIESĂbh7597447wSurvivedOats߂ggg7灇512߁">7173/>About 2ourρρσO77787607320inuteߖ_׊׊׀g57ǃ灇22ׁׁ׀72Lesshan 'WWWVEWW'Ѭ7g2ׁWWze="2">A bout 24oursOat/trr߀ځg> 573灇1,8102075do.7/table>SUMMARYbvTheesultsfxexperimnabbiXshowonsideleriati intoxicityUsing@dose.ndividualsifferedoelyirqistancixrugPatam/)hadYbQpeatmanysthachethodadmin0rbefortisfactoryQcluss`ulddrawn.Ԅik!lhts venounjecwhia:near0.2ramerilPasotatal.imilar{ excepalWrseti(essca@hbservwhetgq1orys.mpsdf=Zh[IinvegYell-markՇ1@ty,hughAyX1quito6ፐ alkaloiȒPorisevl rێ@*Kdic@8rsያv2ndeamh[BUmumtwooducGa7.1;el?:r끷3.1/*ubcueXف1520rQA twe muscu1Ϝ'!s傱m)ԘZ"@lmmidha˦r؅(toP0pes0hal1_ly.eltzAuer,62: 90)Є'c8Ɉco蘩ǷluҀoleeׁOK{`@ikѐWQtissuunequ9?:?;.GGGGGGGDߒverytrik!gO>curarahdalin%HmewaҌphI_.htocol sesy0om f]oi/͈Qsoн́뇧on,xi?dihYhdisaltogBIuc a?=pa88Jg(nϺ҅we`p@?qf@ئhiGkoxicw!!feedingyouthndubcutaneousnjection,lthoughistinct,asoteryreat.tmuchesshanaurel55ducing0D.alsoHobserv)ؒa1ngga؆ǃfwnequal.EXPERIMENTSNUINEAIGSb0???T_Zstudixa4numbdividsewqcon1xfull-g@`8KarrAeasony jiewaySpeciattș+8؃ossibfpinflu0 ځTepчAe8atYoqZQce(訸q.Í_cpPЗ tHH!=ϑb>SUBCUTANEOUSNJECTION4oooojS?ʗES \A'9'P(iἀ/sgui0ig("'360, 30( 290gnkiloA)sѲKrid@ʚh8sePQvulsXlourfȁ␝5ឺdurackC+hae 9inuHjx.epllHsBêR@Iaٹr+#қ9tmp@sideunP 0.3ram׸o1tpysl)esul@a򇌔/nexys'?'dB''''''>E 2ciAqtitHwwwwr GN 20.ee.ׂ", 4972@D詈FebruY11: 3 6b (21J5); 4.15,flex0increas! dHurbedY45hlLparalysis;guineaigyingniside,espiratidifficultndabored.

February 11: 5.05..,uinLfoudead, 2ours15inutexfternjec????>G37.ale.ׂ , 820rams.iecarrotCoaHduryweekrecedythefffei i>////gg 3.3f8.5cp(cent=edubcutaneouslyback; Fvesensitivaniorxtremxparalyzwhe0lefrequspasmspos ,oympto0notief althghatchalltimewwleglooknormal.ottJɍ@____^2: 93O;ithX18????13.e0 6πigggg`March 29: 2.45В(0.194kkilo)????:30:t 4-25ww''''u6wt5vF Y8envio0ooop2somewhm1anorepctngٞw'__ut.THХ pseࢸntabservȋ(f1indicattwoPciۯ/6anipoducalhra臉neathxllow{مws 70=11|firs؅8festbԂhٷnwhileld?oG.v02/wH1)cbatǂ҅lȊxashown,(we,|i0nPЛvPpiab(grrgq)]yKZѓdos0.28adh`&saxpȘer">SERIES Cƒ''' 6YedarkrȔp, 51_OOctob(4:Ϫnq2^ooly3רggggf5!ve;obgoodׂׂׂׂׂԿFv.Autopsy:ongљHkidneyPs8l1neGGGGwwq5hiblGGGG׃׃׃׈GGGGGGGGGGGGGggggGGϋ0dye׋32׋׋׃߃߃߃߆w3: 2.8 3.GGE19WWWWWk;40 vulsɯ@coy156frequspas$xraly,sp!lPҩiortremes.3teu@h8d(ogpȄfloorOwwwwG89festines,ungs,iver.

Guineaig 57.hitendrayemale, 350ms.ieoatsi>߃߃߃߃October 3: 2.15...5c 2centaffeinnjectedubcutaneouslyheack (0.2kilo);40convulsionsthecoy; 5.3>noarkiympto4: 8.aӁ8ve8ct@6:ou(deadt 9 Autopsy:ongeonfcz;dneysptechia;eeastro-eritioooo68.ellowؒ, 785: 11.357.8ȑGGA; 12on,flexesXcreas`s14.2>N samȋtU 7:,ǏLRp񎩏*fattspleen,howXhemorrhagic`ots;xmucosaecrotic`lori( nePflHdwwq9]oi5ooogl5ooϑϑϑϑ,uttъphA`No.wghysensȢyϔo than////WWWWWT15_&y1.rowhblaߵܮߐߐ߃ 442mg??;;unHdrapopriorxtrem`e7ooooGGߌ߂ߌ2T,''$''////!.05???938???AxmpspmadXulHobta^prhi`)(trikρ`aЍ,2eciiswpromorapi fatsgemploylhr'!this____yhseverpYorHpoin!\PbbiaXmimportflu toxicityӉUntunlyYcc8`avail /ntugr`tghsNwsipZ/@ Zrbabil1qyeat.͐@itp6^ׂBCO@(rm*[ ev(dЎsΨ20, 38313.Cenexttpg,rin#jnalyP'ʜC9֒3934xperimentsndicatehatimulationfeagu8sessffectiveromctoberoanuaryAnFebropril,henyrelsouchoxsusceptiblpo(PXprocedure.u(foundresistanceguineaigs1ace0nit1abouwipasre0immhmhP؉a.

R`ibouximpor`(arۄ(connon.iaossedti reasonsUyear؀sevlrieties,!`no؂Aȓe,owفytXupЊ׊уb@sewi(rsng.ɌrhlybaPf߆!caЃs؆ CLBduJˉroooonD0.20@4am>`iloWPmayregardhminmtdwr,epeng+hc&v@Hapid(;X-! quityhap'''$IihWsadAddiytesithHa|^prd<ΓMarch.ԣKuls@Dcr">SERIES Dl'''73 G49.lHW510Js.Ğ(,a1Cevio؋iwwwwvZ 17: 3.., 4c 2:ɗ(0.16)inj@subcuely; 4.40lexp!ed; 5`ymptoȆ7777728: 9{deadizZ18urpAutopsy:ehgibdocav;5leHuаxgInr;picyapoX;">z0{639o`oneekLJ">~12: 115ߒߒ58㒿backg3Հllave4dy5.ة` 435abyG?>3.rߍߍ۱Z颃㏯mǡg____38G 6G늯w焚B; emXQQooonk;dAdggh176Ԍ7777/////////(߄gggg:A[9 app0ntnorȌGveWOM67ߏߦ珵ex8im!\4|taffeinnjectedHtoackubcutaneously; 4.35..,eflexesxcreased,remorsnandlingarked; 5.40noge,ymptomsboutsefore.

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Octob4: 8.50[guavenctXG56.rayteale.ׂ, 440rams.ieoatsi>σσσφ1: 11AreceHd 4.6ca2Hcentsolu (0.2"kilo)bdominalvity;945=1fnessZrigid(qpoPriort@itieincrea82PHYaralyzed.35njHgood@3:till\ςςςςςςύʔ d. AutopsyI:n lHhtung8p`.ӒlxrJ8seXned0touhOthorgansrPυυυϗ__Y5 yellowoj69ooo߃߃߃߉ooj6.5om.(188g_[xitoȗga6g ϖsrkedlygto e1߃x3]foudead?ggger">SERIES Dƒ'''g 67__, 30___߃߃߃ߑ]5Z24o%jecww(2`o)7tetanus—surv,vulsyfҡheatht 2.54Severe缘roHs;dney8techis@gyir3w 3wσσσύލm28jGGFwWIǂǂǂNj7764.row؂blackȋOH05LG뉰3.8穗/5ߋ///ߩߘߘߘߘߘ,h4.1טטFiexactXamЬNo.i Examin3result zexQm stra爬show@thP0.2~=toxictwo琎s (No5958)Xsymptomsqobserwith80u]56ہXourHf adi6apprm@Oeosf.ς3Ȏ"thre-halfHio(r,<,d`Ӿoyromc僐chi0m t_n ygardQefore@H)mubڌ`eKScorrobo0hqBhch(l9sailoyuscula8nPousrpiPoА󉴁ticXm̑[keptnd#IsotىA,Hw,dictT .tmark eciab_Y0uXm8P(fat@–xeasonhvarpread8oȁou1#babil(kewikpibldirence"abetwe(ggabB0̙clsoeʗJr.Ƅpurpmentsferiesereerformed.heesistanceYNo. 63nhisՀPquitetriking.ehunableoxplasuchiscrepysRultbtHedderracticallyionditions+minimumatalosjcaffein,hen0jectinxPitonecavity,Qre0bout 2402508lligramsilxxamountst8bvedrapid(*H`|trastI__چssubcu eously@probyu"attabsorp romwwtya/(issues.

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